A Meta-Analysis Of Risk Factors Of Premature Ovarian Failure In Chinese Population

Objectives Meta-analysis is used to evaluate the incidence of premature ovarian failure(POF)among Chinese people,and acquire risk & protective factors and their associated main strength,so as to provide basis for decision making on POF prevention and clues for further etiology study.Methods PubMed,Medline,Embase,OVID,CBM,CNKI,WAN FANG DATA were searched for relevant literatures in English and Chinese which were published during2000.01-2016.10,The type of literatures are case-control study.According to the standards for literature into and out of screening of literature,Meta-analysis is used to make a systematic analysis.OR&95% confidence interval(CI)represent each effect size range.Test for heterogeneity,sensibility analysis and publication bias assessment are made by Stata 12.0.Results The final included 27 case-control literature,the study has 3249 cases,including control has 3119 cases.The result for Meta-analysis: 1 Risk factors and strength,family history(OR=3.64),mumps history(OR=7.71),immune disease history(OR=6.10),pelvic inflammatory history(OR=2.67),pelvic surgery history(OR=4.92),oral contraceptives(OR=4.17),take immune medicine(OR=3.86),artificial abortion history(OR=3.68),abdominal and pelvic X-ray radiation(OR=2.93),irregular menstruation(OR=8.88),divorce or window(OR=3.06),smoking(OR=4.38),exposure to toxic substances(OR=4.28),dieting(OR=4.17),hair dye(OR=3.91),poor sleep(OR=2.75),drinking(OR=2.64),trauma or exception(OR=8.60),unhealthy emotions(OR=5.30),type A behavior(OR=3.99),high life pressure(OR=2.72),poor interpersonal relationship(OR=1.59).2 Protective factors strength,good mood(OR=0.18),regular consumption of vegetables(OR=0.33),often exercise(OR=0.36)and bean product intake(OR=0.63).3The results of the merge of childbearing history,menarche and hairdressing are not statistically significant in the research(P>0.05).The relationship between POF and these factors above cannot be determined.4 Heterogeneity larger factors(I2)reduce differently,but irregular menstruation,childbearing history,hairdressing,often exercise and bean product intake are highly heterogeneous.The result shows that all the factors mentioned above are basically identical except the factor of often exercise.5 Research factors are evaluated by Egger 's method,the result shows that exposure to bean product intake may exist possible publication bias.Conclusions 1 Tthe risk factors of POF include family history,mumps history,immune disease history,pelvic inflammatory history,pelvic surgery history,oral contraceptives,take immune medicine,artificial abortion history,abdominal and pelvic X-ray radiation,divorce or window,smoking,exposure to toxic substances,dieting,hair dye poor sleep,drinking,trauma or exception,unhealthy emotions,type A behavior,high life pressure,poor interpersonal relationship,the risk factors of POF include good mood and regular consumption of vegetables.2 The relationship between POF and irregular menstruation,childbearing history,menarche,hairdressing,often exercise and bean product intake in the research cannot be determined,Need more data to further explore.3 All these conclusions can be applied to women health education as clinical guidance,so as to prevent or delay the occurrence and development of POF.