Serum Insulin In Patients With Type 2 Diabetes Treated With Insulin Factors Affecting The Level Of Elevation

Objectives to study the influencing factors of insulin levels in patients with type 2diabetes treated with insulin,and to provide more rational,standardized and individualized treatment for type 2 diabetic patients.Methods Select type 2 diabetes mellitus(T2DM)patients with 231 cases,including 113 cases of male,female 118 cases,age 24 ~ 82 years old in department of endocrinolog affiliated hospital of the North China University of Science and Technology,the average age was(57.62 ±10.50)years old.According to the serum insulin level was divided into T2 DM with elevated levels of serum insulin group(case group)36 cases,including 13 cases of male,female 23 cases,age ranged from 39 to 75 years old,the average age(58.75± 8.70);T2DM normal insulin group(control group)195 cases,SPSS was chosen as a random sample of 108 cases,as 1:3 control,including 58 cases of men.50 cases were female,age ranged from 26 to 80 years old,the average age(57.42 ± 10.80)years old.The patients were measured in fasting serum insulin(FIns)and 2 hours postprandial serum insulin levels(2h Ins),and compared between the two groups in gender,age,height,weight,body mass index(BMI),smoking and drinking,uric acid,fasting blood glucose before admission average,before admission application of insulin dose,insulin discharge time,insulin dosage,duration of diabetes,diet and exercise,blood(UA),glycosylated hemoglobin(Hb A1c),fasting blood glucose(FPG),triglyceride(TG),low density lipoprotein(LDL-C),fasting blood sugar(FPG),2h postprandial blood glucose(2h PG),fasting C peptide(FC-P),postprandial 2h C peptide(2h C-P)and insulin resistance index(HOMA-IR),diabetes,hypertension and other indicators.The data was analyzed by SPSS21,The normal distribution of the measure information are expressed as mean ± standard deviation((?) ± s);count data expressed as a percentage,chi square test;risk factors for high serum insulin level in patients with T2 DM by non conditional two classification logistic regression analysis to;P<0.05 there was statistically significant difference.Results Between the two groups in gender,whether diabetes diet or exercise proportion,smoking and drinking history has no constituent ratio and proportion by the chi square test showed that the complications of diabetes,between the two groups in gender,smoking and drinking history of no significant difference(P > 0.05),between the two groups is not diabetic diet or exercise control the constituent ratio of the constituent ratio ofcomplications was statistically significant(P < 0.05),which increased serum insulin levels in the diet and exercise group,the proportion is low,a higher proportion of complications.Between the two groups were TG,UA,insulin,FIns,2h Ins,C-P,2h C-P,HOMA-IR by t test showed that the serum insulin levels in these indicators were significantly higher than the serum insulin level of normal group,the difference was statistically significant(P <0.05);the chi square test and t test with statistical difference index as independent variables,in serum insulin levels as the dependent variable for non conditional two classification logistic regression analysis,the effect of correction of whether diabetes diet or exercise,insulin dosage,admission TG,BMI,UA,C-P,2h C-P,HOMA-IR,diabetic complications and other factors showed that triglyceride(OR=2.34),HOMA-IR(OR=1.21),2h C-P(OR=1.92)is a risk factor for T2 DM patients with high levels of insulin,diabetic diet or exercise is a protective factor(OR=0.19).Conclusions Patients with diabetes,diet,or poor exercise control are at increased risk of elevated insulin levels.Elevated triglycerides are an important factor in the elevation of insulin levels in diabetic patients with insulin.