| Object At present,the detection of non-invasive liver fibrosis grade or cirrhosis is still the difficult point in the clinical work of liver disease.Studies have shown that noninvasive liver fibrosis model APRI and FIB-4 index can be used for significant liver fibrosis(F≥2),This study this study was to explore the diagnostic value of the combination of the two indexes of liver fibrosis significantly,providing the basis of evidence for clinical diagnosis and treatment work.Methods Collected 171 cases of chronic hepatitis b patients with digestive department,and record into the standard of the patient’s general information,blood routine liver function,five items of blood coagulation,and etc.,and at the same time record the liver biopsy pathology biopsy results.Results 1.With the degree of liver fibrosis,APRI,FIB-4 index in different fibrosis stage was statistically significant(P < 0.05);2.According to biochemistry,blood coagulation function and clinical indicators such as the age according to the formula of APRI,FIB-4 values;3.In HBeAg negative aspect,APRI is better than that of FIB-4,the area under the curve is 0.829(0.737,0.921),0.780(0.678,0.883);In respect of E antigen positive,APRI below FIB-4 diagnosis;4.In ALT normal liver fibrosis significantly,APRI boundary value at 0.38 and 66.7% of the sensitivity of the diagnosis of liver fibrosis significantly ex degree of 73.8%,positive predictive value 59.3%,negative predictive value 79.5%;And FIB-4 cutoff is 1.40,the corresponding sensitivity of 33.3%,a specific degree of 54.2%,positive predictive value 56.0%,negative predictive value 31.7%;In respect of ALT elevations,FIB-4,APRI area under the curve is 0.784 [0.689,0.880],0.804 [0.712 0.897];5.The specificity and diagnostic accuracy of the model and the ratio of two were higher than those of the two indexes.Conclusion Two metrics joint can improve the diagnostic value for significant fibrosis patients,It also Provides a new thought of diagnosis for clinical work. |
