The Expression Of COTL– 1,MVD In Cervical Lesions And Research Of The Clinical Significance

Objective : To explore the role and significance of human coactosin-like protein-1(COTL-1)and microvascular density(MVD)in the development and progression of cervical cancer by detecting the expression of both in human cervical cancer.Methods:The expression of COTL-1 respectively in 40 cases of chronic cervicitis,40 cases of CIN I,45 cases of CINⅡ~Ⅲ and 47 cases of cervical cancer were detected by immunohistochemical method.MVD was counted by CD34 staining to detect the number of microvessels.Results: 1.The expression of COTL-1 in the control group was significantly lower than that in the control group in the CIN I,CIN II~III and cervical cancer tissues.The dye ingintensity of COTL-1 was gradually increased by lesions level increased(Z = 6.62,p<0.05).The positive expression rates of COTL-1(86.36%,90.48% and 94.73%,respectively)were significantly higher in the cervical cancer group than those with poorly differentiated,infiltration depth ≤ 1/2 and pelvic lymph node positive(p<0.05),but not with the FIGO staging(p>0.05),and the positive expression rate was 60.00%,57.69% and 57.14%,respectively,and the difference was statistically significant(p<0.05).2.MVD counts increased with the level of cervical lesions increased.The difference between the two groups was statistically significant(p<0.05).In the cervical cancer group,the expression of MVD was correlated with the degree of lymph node metastasis and the differentiation of pelvic lymph nodes,and the positive rate of pelvic lymph nodes was significantly higher than that of negative group(p<0.05).With the increase of histological differentiation of cervical cancer,MVD decreased gradually,the difference was statistically significant(p<0.05).The expression of MVD was not related to FIGO staging and the presence of deep interstitial infiltration(p>0.05).3.The expression of COTL-1 was positively correlated with MVD(r = 0.86,p<0.05).Conclusion: 1.COTL-1 may be involved in the development of cervical cancer by promoting tumor angiogenesis.2.COTL-1 may be related to the infiltration and metastasis of cervical cancer.and is expected to be one of the indicators to predict the progression and prognosis of cervicalcancer patients.COTL-1 may become a new target mole to resist the angiogenesis of cervical cancer.