Correlative Analysis Of MiR-210 Expression And Molecular Typing In Breast Cancer

Objective Micro RNAs are involved in the regulation of cell proliferation,differentiation and survival as a new class of noncoding genes.The target molecule of mi RNA-210 is involved in a variety of metabolic activities in cell survival and proliferation in solid tumors.According to the existing clinical experience and related literature,breast cancer classification of breast cancer is divided into four common subtypes,four subtypes of the treatment effect and prognosis is very different.Recent development of more effective pharmacological means can be used to regulate the activities of mi RNAs,for cancer treatment provides a new treatment ideas.The relationship between the relative expression level of mi RNA-210 and clinicopathological features in invasive breast cancer tissues and adjacent non-cancerous tissues was analyzed to evaluate its role in the development,progression and prognosis of invasive breast cancer.The relationship between the relative expression of mi RNA-210 and the molecular typing of the corresponding cancer tissues in the invasive breast cancer tissues was analyzed and analyzed to predict the mechanism of molecular carcinogenesis in breast cancer.Methods 50 patients' tissue with invasive breast cancer who were diagnosed by our hospital were examined by real-time quantitative RT-RCR(q RT-PCR)to detect the relative expression of mi RNA-210 in breast cancer tissues and normal breast tissues(from the edge of cancer> 5cm)The expression of mi RNA-210 in breast cancer tissues was correlated with tumor molecular typing and the basic clinicopathological features of patients with breast cancer.The relationship between the expression of mi RNA-210 and the molecular genotype and the basic clinicopathological features of breast cancer were analyzed.Results The relative expression level of mi RNA-210 was(4.39 ± 2.86)?g / ml in breast cancer tissues,which was significantly higher than that in adjacent normal tissues(1.94 ± 1.52 ?g / ml,P <0.05)The relative expression level of mi RNA-210 in HER-2 overexpressing breast cancer was(8.32 ± 0.95)?g / ml,followed by tri-negative breast cancer(6.18 ± 0.95)?g / ml in Luminal B(3.77 ± 0.56)and(3.17 ± 0.36)?g / ml,respectively.The relative expression level of Luminal B1 and Luminal B2 was the lowest in the Luminal A type(1.54 ± 0.37)?g / ml,The difference was statistically significant(P <0.05).The relative expression level of mi RNA-210 in invasive breast cancer tissues was significantly different from Her-2 overexpression and triple-negative in Luminal A type,Luminal B1 type and Luminal B2 type,and the difference was statistically significant.The relative expression level of mi RNA-210 in the latter was significantly higher than the former,suggesting that mi RNA-210 may inhibit the expression of ER and PR.There was no significant difference in the expression level of mi RNA-210 between Her-2 overexpression type and triple-negative type in invasive breast cancer.The main difference between the two types of breast cancer was the nature of Her-2 receptor,and to some extent The expression of mi RNA-210 may be independent of Her-2 receptor expression.The relative expression level of mi RNA-210 in invasive breast cancer group was not statistically significant(P> 0.05),but it was not related to other clinicopathological features,such as age,tumor size,histological grade and pathological stage.Conclusion The relative expression of micro RNA-210 in breast cancer tissues was different in different molecular types of breast cancer tissues.There was a certain extent that the expression of micro RNA-210 could be introduced to the breast cancer tissue Which can be used to detect the expression level of micro RNA-210,which can provide theoretical and experimental basis for preoperative diagnosis of breast cancer molecular typing and new treatment of breast cancer.