| Objective To explore the correlation between inflammatory factors(IL-6,TNF-?,IL-1?)levels and cognitive impairment in CSDM,so as to provide theoretical guidance for clinical treatment.Methods60 cases of chronic mental patients with diabetes division in our hospital from Dec2014 to Dec 2016 as the observation group,including 37 cases of male patients,23 female patients,age range 19~53 cases,average age(38.37±9.77)years old,according to the cognitive evaluation the observation group were divided into observation group A(mild cognitive impairment group 39 cases),observation group B(severe cognitive impairment group 21 cases),the observation group A of 39 patients with mild cognitive impairment,the observation group B of 21 patients with severe cognitive impairment.Inclusion criteria:(1)all subjects age ranged from 18 to 55 years;(2)all the patients in the observation group were diagnosed as schizophrenia by ICD-10;(3)the observation group all the patients were in CSDM patients;(4)the patients with type 2 diabetes,FBG?6.1mmol/L or 2h PBG?7.8mmol/L;(5)the patients and their families were informed and signed the informed consent,and approved by the ethics committee of the hospital.Exclusion criteria:(1)Patients with systemic disease;(2)major organ diseases such as liver and kidney of the patients;(3)the patients have a family history of mental illness or mental illness;(4)the patients for nursing or in special physiological period of the patients with women;(5)there is a history of allergies or had received immunosuppressive therapy.40 healthy volunteers(no mental illness history and family history)who were admitted to our hospital during the same period were selected as control group,including 27 male cases,13 female cases,age range 18~54 cases,average age(38.64±9.96)years old.The correlation between the levels of inflammatory factors(IL-6,TNF-?,IL-1?)and cognitive impairment in the two groups were observed.Result Before treatment,the observation group IL-6,TNF-?,IL-1?levels were significantly higher than the control group,with statistical difference(P < 0.05),the observation group after treatment IL-6,TNF-?,IL-1?levels decline,but the decline was not significant compared with before treatment,no statistically significant difference(P > 0.05),Compared with the control group,the observation group symbol encoding,verbal fluency,continuous operation,digital sequence,verbal memory,visual memory,maze,emotional management and the total scores were significantly lower,compared with statistical difference(P < 0.05);The level of inflammatory molecules in the cognitive impairment group was significantly higher than that in the control group,and the level of cognitive impairment of B in the observation group was significantly higher than that in the observation group A,the levels of IL-6,TNF-?,IL-1?were gradually increased,all of which were statistically significant(P<0.05);There was a significant positive correlation between cognitive impairment and inflammatory factors,and the correlation coefficient of IL-6 was the highest(r1=0.738,P<0.05;r2=0.317,P<0.05;r3=0.106,P<0.05);Logistic regression analysis showed that IL-6,TNF-?,IL-1? levels were increased,which were independent risk factors for cognitive impairment.Conclusion The results shows that CSDM patients with cognitive dysfunction and inflammatory factors IL-6,TNF-?,IL-1? were positively correlated;and the results of Logistic regression analysis showed that IL-6,TNF-and IL-1 levels were independent risk factors for cognitive impairment,therefore to detect the levels of inflammatory factors(IL-6,TNF-?,IL-1?)in patients with CSDM,which is helpful for the monitoring of patients' condition and the formulation of treatment plan. |
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