A Meta-analysis:Efficacy Of Thoracoscopy Surgery Versus Thoracotomy For Thymoma

Objective To investigate the effect of Thoracoscopy surgery and Thoracotomy for Thymoma by Meta-analysis.Methods The following electronic databases as PubMed,EMBASE,The Cochrane Library(Issue3,2016),Web of Science,Chinese Biomedical Literature Database,Wanfang Database and China National Knowledge Database were retrieved on computer for randomized controlled trials(RCTs)and cohort studies of comparing Thoracoscopy surgery with Thoracotomy for Thymoma.The retrieval time was from inception to April 2016.Two reviewers independently screened literature according to the inclusion and exclusion criteria,extracted data,and assessed the methodological quality of the included studies.Then data were analyzed by RevMan 5.3 software.Results A total of 5 RCTs and 8 cohort studies involving 1093 patients were included,The Meta analyses showed that compared with Thoracotomy,the Thoracoscopy surgery could shorten operative time[MD=-22.2,95%CI(-32.92,-12.52,P<0.00001],duration of ICU(Intensive Care Unit)stay[MD=-0.76,95%CI(-0.21,-0.30)P<0.00001],duration of hospital stay[MD=-3.71,95%CI(-4.47,-2.96),P<0.00001],duration of pleural drainage[MD=-1.80,95%CI(-2.42,-1.18),P<0.00001]and reduce volume of intraoperative blood loss[MD=-40.37,95%CI(-42.54,-38.20),P<0.00001]and decrease the incidence of postoperative complications[OR=0.19,95%CI(0.11,0.34),P<0.00001],but there was no significant difference in recurrence rate[OR=0.81,95%CI(0.31,2.11),P<0.00001].Conclusion The thoracoscopy surgery can shorten operative time,duration of ICU stay,duration of hospital stay,duration of pleural drainage and reduce volume of intraoperative blood loss and decrease the incidence of postoperative complications,but there was no significant difference in recurrence rate in Thymoma.