Clinical Observation Of Therapeutic Effect Of ZhiBoQingLiTongLuoprescription On HBV Related Glomerulonephritis

Objective: The research goal of this project is to investigate therapeutic effect of Hepatitis B Virus(HBV)related glomerulonephritis and deficiency of liver and kidney plus humid and stasis by applying ZhiBoQingLiTongLuo(ZBQLTL)prescription.Method: Fifty-eight patients with syndrome of HBV related glomerulonephritis from Department of Nephrology,the First Affiliated Hospital of Shandong University of Traditional Chinese Medicine were randomly separated into experimental group and control group with 30 each.Patients from control group were treated by basic treatment of western medicine including liver protection,anti-virus,bring down blood pressure,anti-coagulin,as well as bring down urinary protein.Patients from experimental group were treaded with self-made ZBQLTL prescription based on control group.The treatment period of both groups were 12 weeks.During this clinical process,clinical syndromes,vital signs and laboratory indexes were recorded and quantified to generate therapeutic and safety evaluation.Results: 1.Experimental group has higher therapeutic efficiency(86.6%)than control group(66.5%)(p<0.05),and they has significant difference assessed by Chinese Traditional Medicine evaluation system.2.Experimental group also has significant difference comparing before and after treatment.And the statistical significance revealed that there was greater efficacy on patients from experimental group comparing with those from control group.3.Patients from experimental group have significant differences on bringing down blood urine,protein urine,and inhibiting HBV replication.Conclusions: Combining with western medicine basic treatment,ZBQLTL prescription could significantly release clinical syndrome.i.e.bringing down blood urine,protein urine,and inhibiting virus replication in HBV related glomerulonephritis patients.Furthermore,it is more safety than uniquely applying western medicine treatment.It suggested that combination of Chinese traditional and western medicine had great potential on glomerulonephritis therapy and deserved clinical expansion.