| Objective: To detect the plasma levels of 5-Hydroxytryptophan (5-HT),substance-P(SP), vasoactive intestinal peptide (VIP) and gastrin (GAS) in children with Henoch-Schonlein Purpura(HSP) including acute period, recovery period and normal children in order to have a better understanding of the changes and pathogenesis of intestinal neuroendocrine in children with HSP.Methods: 40 children with HSP admitted to the First Affiliated Hospital of Kunming Medical University from May 2015 to September 2015 were as study group and 30 normal volunteer students in some primary school were as control group. The levels of SP, VIP and GAS in the plasma in the study and control group were detected by radioimmunoassay. The level of 5-HT in the plasma in the study and control group were detected by double antibody sandwich enzyme-linked immunosorbent assay(ELISA) method. All data were processed by statistical methods.Results: The plasma levels of 5-HT, SP and VIP in children with HSP at acute period were higher than that in normal children and in children with HSP at recovery period (P<0.05). The plasma levels of 5-HT, SP and VIP have no difference between in children with HSP at recovery period and the normal group (P>0.05). The plasma level of GAS in children with HSP at acute period was lower than that in normal children and in children with HSP at recovery period (P<0.05). The plasma level of GAS had no difference between in children with HSP at recovery period and the normal group (P>0.05). There were no different plasma levels of 5-HT, SP, VIP and GAS among the simple type, abdominal type and other types of HSP (P>0.05).Conclusion: 1.The plasma levels of 5-HT, SP, VIP and GAS are variable in children with HSP including acute and recovery period. It is suggested that these changes may affect the onset and prognosis of HSP. 2. No different plasma levels of SP, VIP, 5-HT and GAS among the simple type, abdominal type and other types of HSP. |
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