| ObjectiveTo observe the changes of inflammatory markers in patients with Lower extremity arteriosclerosis obliterans between preoperative and postoperative,and to investigate the effect of Shuxuetong injection on the level of inflammatory markers in patients with atherosclerosis after endovascular treatment.MethodsSixty patients with lower extremities arteriosclerosis obliterans were divided into control group and Shuxuetong group(30 cases in each group).Basic treatment: 60 patients before endovascular treatment,aspirin enteric-coated tablets 100 mg orally every day,atorvastatin calcium tablets 20 mg per night orally;intraperitoneal aspiration aspirin enteric-coated tablets 100 mg orally,atorvastatin calcium Tablets 20 mg per night orally.Joint stent implantation,plus clopidogrel tablets 75 mg per night orally.Control group: the basic treatment and alprostadil injection 10 ug compatibility saline100 m intravenous infusion,qd.Treatment for 2 weeks.Shuxuetong group: basic treatment + saline 100 ml plus topical injection 10 ug intravenous infusion,day 1,treatment 2 weeks;Shuxuetong injection 6ml add saline 100 m intravenous drip once a day,treatment 2 week.The levels of plasma Hs-CRP,fibrinogen,platelet count,white blood cell count were measured on the 2nd day after admission,on the second day after endovascular treatment,on the 10 th day after endovascular treatment.To observe the changes of inflammatorymarkers before and after treatment and the effect of Shuxuetong injection on the level of inflammatory markers.Results1.There was no significant difference in sex,age,complication,course of disease and number of implanted stents between shuTuTong group and control group(the independent data were used for t-test and chi-square test,P> 0.05).Admission Day 2Inflammatory Index Level:WBC(6.85 ± 1.32)× 109 / l,PLT(214 ± 34)× 109 / l,hs-CRP(3.25 ± 1.78)mg / l,Fib(3.55 ± 1.23)g / l for control group,WBC(6.68 ± 1.19)× 109 / l,PLT(220 ± 41)× 109 / l,hs-CRP(3.48 ± 2.11)mg / l,Fib(3.61 ± 1.06)g /L for Shuxuetong group.There was no significant difference between the two groups(P> 0.05).2.Compared with preoperative,the levels of WBC(9.78±1.53)×109/l,PLT(352±12)×109/l,hs-CRP(52.44±27.56)mg/l,and Fib(5.03±1.56)g/l on the second day after operation in the control group were significantly higher than those in the control group(P<0.05),and the increase of hs-CRP was significant(P <0.01).The levels of WBC(7.12 ±1.20)109 / l,PLT(225 ± 20)× 109 / l,hs-CRP(11.16 ± 3.62)mg / l,Fib(3.66 ± 1.25)g / l were statistically significant(P<0.05)compared with those on the second day of endovascular treatment.Hs-CRP decreased significantly(P <0.01).3.Compared with preoperative,The levels of WBC(9.65 ± 1.45)× 109 / l,PLT(310± 20)× 109 / l,hs-CRP(41.33 ± 25.28)mg / l,Fib(4.40 ± 1.11)g / l were statistically significant(P <0.05)on the second day after operation was statistically significant(P<0.05)in Shuxuetong group.The increase of hs-CRP was statistically significant(P <0.01).The levels of WBC(6.31 ± 1.31)109 / l,PLT(209 ± 16)× 109 / l,hs-CRP(6.21 ± 2.05)mg / l,compared with the second day of endovascular treatment,Fib(2.52 ± 1.31)g / l decreased statistically(P <0.05).Hs-CRP decreased significantly(P <0.01).4.On the second day of treatment,There was no significant difference in WBC level between the two groups(P> 0.05).However,the levels of PLT,hs-CRP and Fib in the conventional treatment group were significantly higher than those in the control group(P<0.05);On the 10 th day of treatment,The levels of WBC,PLT,hs-CRP and Fib in Shuxuetong group were significantly lower than those in the conventional treatment group(P <0.05),and the difference of WBC and PLT level was significant(P <0.05).Hs-CRP and Fib levels were significantly different(P<0.01).5.Comparison of simple balloon dilatation with stent implantation: On the second day after operation,the levels of WBC,PLT,hs-CRP and Fib were significantly higher than those of simple balloon dilatation(P <0.05).The difference of hs-CRP level was statistically significant(P <0.01).On the 10 th day after operation,the differences of PLT,hs-CRP and Fib were statistically significant(P <0.05).The difference of hs-CRP level was statistically significant(P <0.01).Conclusions1.The cavity after inflammation markers were significantly higher than those before treatment(P < 0.01),stent is more obvious than mere balloon expansion increased(P <0.01).2.ShuXieTong injection can obviously reduce the lower limb arteriosclerosis sex lumen occlusion disorder patients after treatment the hs-CRP and Fib level(P< 0.01). |
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