| Combined with the literature and our previous clinical experience,we believe that the spleen and kidney deficiency and blood stasis of the "virtual standard real" is the common pathogenesis of most of the weak sperm disease,especially for asymptomatic asthenospermia.Spleen and kidney deficiency was the basis,blood stasis was the trend,and Fuzheng Quxie was the basic rule.Through the " Fuzheng Quxie " eventually reach the body "Y YinpingYangmi " state and the treatment of asthenospermia.Erxian Bushen Yijing Decoction is the experience prescription for weak sperm disease at the Third Affiliated Hospital of Beijing University of Traditional Chinese Medicine,and was from "zanyudan"in the "Jing Yue book".The prescription was also in the Qing · Ye Tianshi "secret seed seed sapphire" documented:Rehmannia,Atractylodes,Angelica,medlar,fried Eucommia,Curculigo,Epimedium,cornus,Cistanche,fried leek seeds,Cnidium,Morinda,aconite,cinnamon,for the treatment of men with impotence failure,years of lack of child.Single drug composition and dose:Rehmannia 24g,Atractylodes 24g,Angelica 18g,medlar 18g,Curculigo 12g,Morinda 12g,Comus 12g,Epimedium 12g,Cnidium 6g,Codonopsis 15g,White Flower Grass 10g,dandelion 10g,Poria 15g,bixie 10g,plantago 10g.To retain the original Epimedium,Curculigo,Morinda officinalis kidney qi,kidney yang,Rehmannia glutinosa plus cornus,wolfberry fruit essence and blood,Zishenyin,Codonopsis,Atractylodes,Poria taste tonic,plantago,Dandelion,Hedyotis diffusa heat dampness detoxification,angelica blood,Cnidium itself can both warm kidney,but also dampness insecticide.In this decoction,epimedium is Xin,Gan,warm,belong to the liver and kidney,can yishen and help yang.The traditional Chinese medicine pharmacology also proved that Epimedium can improve the function of male testicular stromal cells,increase the body's serum levels of testosterone.Rehmannia glutinous rice warm and moisturizing into the kidney,good yin and blood,Yi Jing fill marrow.The two drugs combined with kidney yang,Yi Jing fill marrow,as Jun medicine,and to "kidney reproduction" effect;curculigo,Morinda officinalis kidney qi,kidney yang,and enhance the efficacy of epimedium and yishen help yang;cornus,wolfberry fruit essence and blood,kidney yin,increase the effect of Rehmannia glutinosa kidney essence;Codonopsis,Atractylodes,Poria replenishing temper,more able to benefits of congenital;so as Chen medicine,to achieve the effect of Bushenyijing spleen;at the same time accompanied by plantaginis heat dampness,;yam rhizome Tongli bladder waterway,red white will turbidity;Dandelion detoxification,diuretic Sanjie,Hedyotis diffusa detoxification,diuretic dehumidification,angelica blood;Cnidium in addition to warm kidney impotence increase monarch and medicine,but also dampness insecticide;together to achieve the role of heat and dampness and blood circulation detoxification.All sides on the one hand kidney essence and spleen,replenishing qi and blood,to restore the "kidney reproductive" function,On the other hand to remove the fine room hot and humid,toxic turbidity,blood stasis,to improve the purpose of sperm motility.Always for kidney,Yijing,spleen,detoxification of the law,both the spleen and kidney to achieve righting and "cure" the purpose,but also blood stasis detoxification Quxie and"temporary" means.Its prescription thinking just for the spleen and kidney deficiency stasis of asymptomatic weak sperm disease of the basic pathogenesis.[Purpose]To observe the clinical efficacy and safety of Erxian Bushen Yijing Decoction in improving sperm motility of asymptomatic asthenospermia.To explore the role of"Fuzheng Quxie" to achieve the "YinpingYangmi" state of traditional Chinese medicine in the treatment of asthenospermia.[Method]we designed 72 patients with asymptomatic oligospermia were randomly divided into treatment group and control group.Treatment group used Erxian Bushenyijing detoxification side free decoction granules daily 1,sooner or later the semi-agent for treatment,and the control group used L-carnitine oral solution each time 1,2 times a day for treatment,treatment lasted 11 weeks without interruption.The curative effect of Erxian Bushen Yijing Decoction on patients with asymptomatic oligospermia was evaluated by the method of control before and after treatment.The changes of sperm motility and motility of semen PR and(PR + NP)were observed,and the effects of drug side effects were observed.[Result]The percentage of spermatozoa,the percentage of forward spermatozoa and the difference before and after treatment were normal distribution before and after treatment.The percentage of spermatozoa in the treatment group was significantly higher than that in the control group(P<0.01).There was no significant difference in the percentage of spermatozoa in the control group(P<0.05).There was no significant difference in the percentage of spermatozoa between the control group and the control group(P<0.05).The percentage of sperm motility and sperm percentage in the two groups were statistically significant(P<0.05),using t test.The difference of the total viability difference between the sperm and the percentage of the spermatozoa before and after the treatment was statistically significant(P<0.05)The difference was statistically significant(P<0.01).The effective,effective and ineffective cases in the treatment group were 18,12,5 cases.The control group was effective,effective,invalid cases were 11,11,13 cases.The overall efficacy of sperm motility in the two groups was statistically significant(P<0.05)by Mann-Whitney U test.There were no significant local and systemic adverse reactions such as dizziness,headache,abdominal pain,diarrhea,nausea and vomiting during the treatment of the patients in the treatment group except the control group 1 patient with drug allergy and 1 patient in the treatment group.[Conclusion]The use of Erxian Bushen Yijing Decoction treatment of asymptomatic weak sperm disease have a good effect. |
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