Research On Combined Targeted Intraopetative Radiotherapy For Centrally Located Hepatocellular Carcinomas And Initial Exploration Of Clinical Efficacy

Objective To carry out the combined targeted intraopetative radiotherapy for centrally located heyepatocellular carcinomas(HCC)and to explore the safety and clinical efficacy.Methods A total of 79 patients with centrally located HCC who underwent hepatectomy were divided into two groups:experimental group(combined targeted intraopetative radiotherapy group,32 cases)and control group(simple surgical group,47 cases).To carry out intraoperative electron radiation therapy on patients in the experimental group after surgical removal of the tumor,and patients in the control group lacked of intraoperative electron radiation step.The intraoperative and postoperative situations of patients in two groups were compared.Results No postoperative 30-day mortality happened in all patients.Average total operation time(319176 min)of patients in the experimental group is longer than that in the control group(233 + 76 min,P = 0.000).Patients in the experimental group had a significantly higher AST level at postoperative day 1(P = 0.031)and a significantly low PTA level at postoperative day 3(P=0.007)and d7(P=0.007).There were no significant differences between the two groups regarding in hospital stay or postoperative morbidity,including hepatic insufficiency,ascites,pleural effusion,infection,bile leakage and intestinal ventilation time(P>0.05 for all).No significant differences were found between the two groups regarding ALT?TBIL?ALB during any postoperative stage(P>0.05 for all).Conclution The combined targeted intraopetative radiotherapy technology may increase the operation time,and slow down the postoperative early recovery of liver function,but it is safe and feasible.