Prognosis Of Radical Resection Of Hepatocellular Carcinoma Originating In The Caudate Lobe And Centrally Located Hepatocellular Carcinoma

Objective:To investigate the clinicopathologic factors and survival of patients who underwent radical surgical resection for hepatocellular carcinoma(HCC) originating in the caudate lobe and centrally located HCC. Methods:The clinicopathologic data of 26 patients with HCC originating in the caudate lobe and 115 patients with centrally located HCC who underwent radical surgical resection from The Department of Hepatobiliary Surgery of First Affiliated Hospital of Fujian Medical University and The Mengchao Hepatobiliary Hospital of Fujian Medical University from June 2003 to December 2015 was assessed. Clinicopathologic factors and survival rates were compared between the two groups. Results:The clinical backgrounds of patients with HCC originating in the caudate lobe and centrally located HCC had no significant difference(P > 0.05). The average operation time which was 157.54±51.76 min of HCC originating in the caudate lobe was longer than centrally located HCC which was 130±51.59 min. HCC originating in the caudate lobe was associated with less frequent cirrhosis than centrally located HCC. The two groups of patients had no postoperative bleeding, bile leakage, liver function failure and other serious complications. There were no perioperative death in all patients.The median follow-up time was 27.5 and 31.0 months in HCC originating in the caudate lobe and the centrally located HCC, respectively. The 1-, 3- and 5- year disease-free survival rates were 67.7%, 41.9% and 33.5% for patients with HCC originating in the caudate lobe, and 82.9%, 59.0% and 46.5% for patients with centrally located HCC(P=0.118).The 1-,3- and 5-year overall survival rates were 90.5%,66.5% and 50.6% for patients with HCC originating in the caudate lobe, and 92.9%, 74.7% and 63.6% for patients with centrally located HCC(P=0.468). Conclusions:1.Radical surgical resection was an effective treatment of HCC originating in the caudate lobe and centrally located HCC, and the operation is safe and feasible;2.The prognosis of patients with HCC originating in the caudate lobe was as good as centrally located HCC.