Study On The Correlation Between Senile Degenerative Valvular Heart Disease And Osteoporosis

Objective:The correlation between SDHVD and bone mineral density was analyzed by analyzing the clinical characteristics,bone mineral density,left ventricular systolic function and the lowest bone mineral density(T)and sex in elderly patients with senile degeneratedheart valvular disease(SDHVD).Methods:Collected from March 2015 to September 2016 in Nanchang University Second Affiliated Hospital of Cardiology Hospital patients(age ≥ 60 years),randomly selected 129 cases,all do echocardiography,according to the old heart disease diagnosis of heart disease,69 cases of aortic valve calcification in patients with SDHVD group,including 28 males,41 females,60 patients without SDHVD as the control group,including 37 males and 23 females.The use of Philips IE33 color Doppler ultrasound diagnostic apparatus to observe the aortic valve and left ventricular systolic function,the United States GE Prodigy dual energy X-ray absorptiometry(DXA)for the determination of bone mineral density.The clinical characteristics of SDHVD group and control group and the difference of bone mineral density were analyzed.The left ventricular systolic function indexes of SDHVD group were analyzed by linear correlation with the lowest T value of bone mineral density.Results:1.SDHVD group and the control group compared the clinical indicators: 25-hydroxy vitamin D3 [25(OH)D3],parathyroid hormone(PTH),alkaline phosphatase(ALP),low density lipoprotein cholesterol(LDL-C(P <0.05).There was significant difference between serum calcium(Ca2 +),total cholesterol(Tc),triglyceride(TG),high density lipids Protein cholesterol(HDL-C)the difference was not statistically significant(P> 0.05)2.SDHVD group and control group in the lumbar spine and proximal femur BMD value comparison.SDHVD group lumbar vertebral bodies 1(Lumbar1,L1),lumbar vertebral bodies 2(Lumbar2,L2),lumbar vertebral bodies 4 vertebral body(Lumbar4,L4),femoral Neck(Neck),the Word’s triangle(Ward ’s),big rotor(Troch)compared with control group difference was statistically significant(P < 0.05),while lumbar vertebral body 3(Lumbar3,L3)comparative differences between groups have no statistical significance(P > 0.05).3.SDHVD and OP were significantly correlated with gender.4.There was a positive correlation between the lowest T value and the left ventricular ejection fraction(LVEF)in SDHVD patients(r =-0.355,P <0.01).Compared with the control group,the color Doppler ultrasonography(R =-0.229,P <0.05).The higher the LVEF,the lower the ABFV and the lower the T value of bone mineral density.(AD),left atrial diameter(LAD),left ventricular wall thickness(LVPW),interventricular septum thickness(IVST)and lowest T value were not statistically significant(P> 0.05).5.The average bone mineral density of the femoral neck in the patients with severe aortic valve was significantly higher than that in the control group and the mild stenosis group(P <0.05).The severe degeneration of the aortic valve was more susceptible to osteoporosis.There was no significant difference in the mild stenosis of the aortic valve,moderate stenosis of the aortic valve and the average bone mineral density of the lumbar spine and femur neck(P> 0.05).Conclusion:1.SDHVD patients 25-hydroxyvitamin D3 [25(OH)D3],parathyroid hormone(PTH),alkaline phosphatase(ALP),low density lipoprotein cholesterol(LDL-C),lipoprotein(LPA)Homocysteine(Hcy)abnormality.2.SDHVD was significantly related with osteoporosis.SDHVD patients with lumbar spine,femoral neck proximal bone mineral density was significantly lower.3.Women susceptible to SDHVD and osteoporosis.4.The lowest bone mineral density(BMD)and left ventricular ejection fraction(LVEF)and aortic valve blood flow velocity(ABFV)in SDHVD patients.The smaller the LVEF,the higher the ABFV and the lower the bone mineral density.5.Aortic valve severe stenosis in patients with bone mineral density decreased more significantly.