Characterization And Properties Of Gallium-doped ?-tricalcium Phosphate As Bone Substitute

Bones are the hardest organ in the human body and have an important effect on people's normal life.Once the bone is damaged,it will cause great harm to the human body.In recent years,more and more patients with bone injuries,commonly used in clinical treatment is bone repair material filling.The composition of ?-TCP in inorganic bioceramic materials is similar to that of inorganic salts in the human body,and has good biocompatibility and biodegradability in the human body,calcium and phosphorus which comes from its degradation can be absorbed by the body for bone reconstruction,and it is one of the key directions in bone repair field.In order to further improve the performance of ?-TCP in bone repair process,ion doping method can be used to change its physical and chemical properties and biological properties.Many trace elements in the body have important biochemical effects.Gallium as a non-essential trace elements in the human body can inhibit osteoclast reabsorption,inhibit osteolysis,prevent bone calcium release,change the bone type?collagen and fibrin gene expression.It is conducive to the new bone,the formation,but also increase the bone calcium and phosphorus content.Therefore,this subject doped gallium into ?-TCP in order to achieve the purpose of modification.In this experiment,0%,5%,10% gallium-doped ?-TCP powder was synthesized by wet process according to the ratio of(Ca + Ga)/ P = 1.5.XRD showed that the gallium-doped ?-TCP bone repair material remains pure and better crystallinity.The introduction of gallium leads to the shrinkage of ?-TCP,the greater the amount of gallium doping,the more obvious the volume shrinkage of bone repair.FTIR analysis showed that the characteristic peak intensity of ?-TCP decreased with the increase of gallium ion incorporation.SEM analysis showed that the macropore structure of gallium-doped ?-TCP had a large pore structure and good microporous structure,which was beneficial to the repair of bone tissue and accorded with the requirement of bone substitute material.In the preparation of gallium-doped ?-TCP repair material,the choice of concentration of 5 wt% of the polyvinyl alcohol solution as a binder,25 wt% stearic acid as a porogen,can make gallium doped ?-TCP is optimal between mechanical strength and porosity,and no impurities are introduced.The degradation of gallium-doped ?-TCP repair materials was carried out in simulated body fluids.XRF and FTIR showed that the surface of the gallium-doped ?-TCP repair material on the surface of bone-like apatite material deposition,with the gallium doping amount increases,the new generation of a certain degree of crystallinity.Cell proliferation assay performed using the MTT assay results showed that the gallium-doped ?-TCP,without cytotoxicity,have a certain role in promoting.ALP assay showed that the incorporation of gallium-?-TCP repair could promote the secretion of ALP in osteoblasts.According to a series of test results,we can see that the gallium-?-TCP has good biodegradability and biocompatibility,and is a promising bone repair material.