Longitudinal Changes Of Vaginal Microecology In 50 Pregnant Women During Pregnancy

Objective:To describe longitudinal changes in pregnant women vaginal flora distribution.Methods: 56 pregnant women with asymptomatic healthy singleton pregnancy were selected from Yiji Shan Mountain Hospital of Wannan Medical College from November,2015 to February,2016.They were divided into early pregnancy(11.2 ± 1 weeks),middle pregnancy(21.6 ± 3.6 weeks)(33.2 ± 3.4 weeks),taking 1/3 of vaginal wall secretions,p H measurement,cleanliness,H2O2 detection and aerobic bacteria culture,and stained by Gram stain in the oil under the microscope.The status of vaginal microflora of the vaginal flora was evaluated,including the diversity of bacteria,microscopic inflammatory response,dominant bacteria.Results:(1)56 cases of pregnant women,due to abortion,halfway to abandon the investigation and other factors,6 cases of subjects off,the final 50 cases to complete the entire experiment.50 cases of pregnant women,22 cases of early pregnancy(44.0%)had normal vaginal microflora,of which 18 cases(81.8%)maintain normal vaginal microecology throughout pregnancy.28 cases(56.0%)had imbalance vaginal microecology in early pregnancy,of which 18 cases(64.2%)converted normal vaginal microecology at the second trimester or third trimester.(2)Part of the asymptomatic bacterial vaginosis in the absence of drug treatment can be spontaneous regression(48%)with the increase in gestational age,but Asymptomatic vulvovaginal candidiasis can be throughout the pregnancy if it untreated..(3)The imbalance vaginal microecology of H2O2 negative,high vaginal p H is difficult to change into normal vaginal microecology.(4)Vaginal aerobic bacteria culture results are based on Staphylococcus epidermidis,the second is Candida.Lactobacillus was not cultivated?Conclusion: The data show that the vaginal microenvironment during pregnancy is dynamic,with the increase in gestational age,lactobacilli tend to maintain the balance of vaginal microecology,and can inhibit the pathogens over-breeding by the excessive regulation,also can make some asymptomatic of bacterial vaginosis to normal,re-establishment of micro-ecological balance to restore vaginal flora diversity in order to avoid complications of pregnancy.We can comprehensively understand the diversity of female reproductive tract microbial flora diversity throughout the development of pregnancy and how to deal with micro-ecological imbalancerelated diseases has laid a solid basis through the evaluation of vaginal micro-ecology and flora culture.