| Objective: To evaluate the effect of the method of Yang Yin Yi Qi An Shen among the Qi Yin Liang Xu stage ?-? non-small cell lung cancer (NSCLC) related insomniacs, we compared the efficacy of Bai He Gu Jin Tang combine Huang Lian E Jiao Tang with that of zolpidem. Through the analysis of sleep structure and change of cortisol, discussing the internal treatment mechanism.Methods: We selected 90 Qi Yin Liang Xu stage ?-?NSCLC insomniacs from Navy General Hospital during November, 2015 to December, 2016. We randomly divided them into two groups: the Traditional Chinese Medicine group in which patients were treated with Bai He Gu Jin Tang combine Huang Lian E Jiao Tang for two weeks, and the western medicine group in which patients were treated with zolpidem for two weeks. We evaluated the effect of the two therapies through Traditional Chinese Medicine Efficacy Standards (2012 edition). We also use Pittsburgh Sleep Quality Index (PSQI) and Actiwatch to measured the patients' sleep quality before the treatment, on the 7th and 14th day of treatment, on the 14th day after treatment respectively. Saliva Cortisol will be test before and after treatment.Results: In total 90 patients take part in our study. 45 cases in the Traditional Chinese Medicine group, fall off 2 cases, while 45 cases in the western medicine group, fall off 3 cases. On the 14th day of treatment, the changes of patients, PSQI score, sleep time, sleep latency, Number of Nocturnal Awakenings(NWAK), sleep efficiency has statistically significant difference (P< 0.05). The results of effective rate (69.8% vs.69%), PSQI score (8(4) vs. 7.5(5),P>0.05),sleep time (6.87±0.71h vs. 6.58±0.7h,P>0.05) between the two groups had no differences in statistics. But patients in traditional medicine group had significantly higher time of onset latency than those in western medicine group (37.28±13.65min vs. 30.12±8.14min, P<0.05); The number of patients whos sleep efficiency are more than 75% in TCM group is higher than western medicine group, the difference has statistical significance (P<0.05). On the 14th day after treatment, the effective rate in traditional medicine group decreased to 55.8%, while that in western medicine group decreased to 26.2% (P<0.05). Besides,patients in traditional medicine group had significantly lower PSQI score (9(4) vs.10.5(3.25), P<0.05) and longer sleep time (6.44(1.09)h vs. 5.83(0.97)h, P<0.05). The time of onset latency, NWAK, sleep efficiency between the two groups showed no significant difference (P>0.05). The change of two group's SC has no statistically difference after treatment(P>0.05). After 14 days treatment,the symptoms of Traditional Chinese Medicine group, such as cough(22/9), pant(28/10), sweat(22/12),chilly(31/16),fatigue(34/14),thirst(25/12),were improved significantly, which is statistically significant difference to compared with western medicine group (P<0.05).Conclusion: It's effective to treat insomnia with the method of yang yin yi qi an shen by using Bai He Gu Jin Tang combine Huang Lian E Jiao Tang among stage ?-?NSCLC. Bai He Gu Jin Tang combine Huang Lian E Jiao Tang can reduce the PSQI score, sleep latency, Number of Nocturnal Awakenings and lengthen the sleep time,improve the efficiency of sleep time, which is also showed by zolpidem. Bai He Gu Jin Tang combine Huang Lian E Jiao Tang could improve the NSCLC related symptoms, but is weaker than zolpidem in reducing the time of onset latency,however, its effective time is longer than zolpidem. |
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