| Objectives: to study the alteration in bone mineral density in patients with urolithiasis in Guangxi province, determine whether urolithiasis is related to bone mineral density and determine whether it is necessary to measure bone mineral density routinely in patients with urolithiasis.Process: 115 cases of clinical data of patients with urolithiasis, who were admitted from Department of Urology, the First Affiliated Hospital of Guangxi Medical University, were assembled from October 2015 to March 2016, 113 cases of clinical data of subjects with medical examination in our hospital assembled at the same period. All clinical data of male subjects were distributed into two groups: stone group and control group, as well as female subjects.Comparison of bone mineral density in lumbar spine and hip was performed between stone group and control group. Incidence of osteopenia and osteoporosis in male or female participants with and without urolithiasis was also calculated respectively. We divided male calculi patients into small stone group (<2.0cm) and large stone group(≥2.0cm),applied independent sample t test to compare the difference of various data and used Pearson or Spearman correlation analysis to test linear associations among continuous variables.Results: There were 115 cases of patients with urolithiasis and 113 cases of healthy subjects. Bone mineral density in the lumbar spine and hip was statistically significantly lower in both sexes compared with healthy subjects(P<0.05), but age, weight and BMI were no statistically significantly difference(P>0.05). Incidence of osteopenia and osteoporosis in male or female patients with urolithiasis was statistically significantly higher than those of subjects without urolithiasis(P<0.05). And we also found similar results in postmenopausal female and male above or below 50 years old patients (P<0.05).Incidence of osteopenia and osteoporosis in premenopausal female patients with urolithiasis was higher than those of subjects without urolithiasis, but there was no statistically significant difference(P>0.05). Male patients with urolithiasis were divide into small group (<2cm) and large group (≥2cm) according to the size of stones. There were no statistical significance in age, height, weight, body mass index, systolic blood pressure, diastolic blood pressure, creatinine clearance rate, serum uric acid, serum calcium, hemoglobin, bone mineral density of femur neck and trochanter between the two groups(P>0.05). Bone mineral density in whole lumbar, whole hip and Ward’s region was statistically significantly lower in large stone group compared with small one(P<0.05).There were statistically significantly longer duration of urolithiasis and more numbers of urinary calculi in large stone group compared with small one(P<0.05).Conclusion: There was a high incidence of osteopenia and osteoporosis in patients with urolithiasis in Guangxi province, thus it was necessary to carry out routine bone mineral density examination in patients with urolithiasis. The size and amount of urolithiasis were negatively correlated with bone mineral density of whole lumbar and hip, and it is suggested that bone mineral density should be checked early in order to early diagnosis and early treatment in patients with large stones and large number of urolithiasis. |
