Research On Clinical Efficacy Of Asthma Formula In Treating Mild And Moderate Acute Exacerbation Of Bronchial Asthma

OBJECTIVE: To observe the clinical effects and safety of the Asthma Formula 1/2 and the Asthma Formula 1/2 combined with Salmeterol Xinafoate and Fluticasone Propionate Powder for Inhalation in the treatment of mild to moderate asthma(Heat or Cold Wheezing),to further verify the feasibility of traditional Chinese medicine in the treatment of bronchial asthma,to explore the mechanism of Asthma Formula for reducing airway inflammation and improving lung function,and to find a significant asthma therapy with milder side effects.Methods: According to system randomization method,the standard 90 cases of mild and moderate bronchial asthma patients,who were diagnosed with cold or heat wheezing,were randomly divided into Western medicine group,Chinese medicine group,Chinese and Western medicine group,29,29,32 cases respectively.Another 30 randomly selected healthy people were in the blank control.The Western medicine group was treated with Salmeterol Xinafoate and Fluticasone Propionate Powder for Inhalation.Chinese medicine group was treated with Asthma Formula——according to syndrome differentiation;Cold Wheezing was treated with Asthma Formula 1 and Heat Wheezing was treated with Asthma Formula 2.On the basis of treatment in the Western medicine group,Chinese and Western medicine group was treated with Asthma Formula1/2 according to syndrome differentiation in the same time.The course of treatment was 4 weeks.The changes of symptoms and signs,Tumor Necrosis Factor-?(TNF-?),interleukin-8(IL-8),FeNO,EOS and lung function were recorded before and after the trial.And the assessment of asthma control,ACT questionnaire,Chinese medicine grading evaluation.SPSS17.0 statistical software was used to analyze the indexes.Results: 1.The clinical effective rate was 96.88% in the Chinese and Western medicine group and significantly higher than that in the traditional Chinese medicine group(75.86%)and Western medicine group(75.00%);the difference was statistically significant(P<0.05).There was no significant difference in effective rate between Chinese medicine group and Western medicine group.2.Asthma control level: The control rate of asthma in Chinese and Western medicine group was 96.88%,which was significantly better than that in traditional Chinese medicine group(72.41%)and Western medicine group(71.43%);the difference was statistically significant(P<0.05).There was no significant difference in asthma control rate between Chinese medicine group and Western medicine group.3.The score of main symptoms of traditional Chinese medicine: After treatment,the total and single score of main symptoms of traditional Chinese medicine of the patients in three groups decreased significantly than the same group before;the difference was statistically significant(P<0.01).The score of Chinese and Western medicine group was lower than that of Chinese medicine group and Western medicine group;the difference was statistically significant(P<0.05).There was no significant difference between Chinese medicine group and Western medicine group(P>0.05).4.Inflammation control indicators: The levels of TNF-?,IL-8,FeNO and EOS of the patients in three groups decreased significantly than the same group before treatment,the difference was statistically significant(P<0.01).The level of Chinese and Western medicine group decreased more obvious than the other two groups;the difference was statistically significant(P<0.05).There was no significant difference between Chinese Medicine group and Western Medicine group(P>0.05).5.Evaluation of lung function: After treatment,the FEV1,FEV1 / predicted %,FEV1 / FVC% and PEF of the patients in three groups were significantly improved than before(P<0.01).The level of Chinese and Western medicine group improved more obviously than the other two groups;the difference was statistically significant(P<0.05).There was no significant difference between Chinese Medicine group and Western Medicine group(P>0.05).6.Dosage of Hormone:The times of using Salmeterol Xinafoate and Fluticasone Propionate Powder for Inhalation and the dosage of fluticasone propionate in the patients of Chinese and Western medicine group was lower than that of Western medicine group(P<0.05).7.Safety: During the study period,the three groups of patients did not have obvious adverse drug reactions.Conclusion:Asthma Formula 1/2 has definite therapeutic effects on patients with mild to moderate asthma(Cold or Heat wheezing)and is safe.Combined with Salmeterol Xinafoate and Fluticasone Propionate Powder for Inhalation,it can better improve the clinical symptoms of asthma,relieve airway inflammation,and reduce the dosage of hormones.It is worthy of promotion in clinical practice.