The Study Of Professor Zhou Naiyu's Experience In Treating Rheumatoid Arthritis Based On The Data Mining Method

BackgroundRheumatoid arthritis is an autoimmune disease characterized by chronic erosive arthritis.It's associated disease of traditional Chinese medicine of rolls for "bi bing".There is currently no cure method of the disease,the main purpose of western medical treatment is to improve symptoms,prevent and reduce damages of joints and bones.Chinese traditional treatment of bi bing has accumulated rich experience in diagnosis and treatment,it's based on syndrome differentiation and individualized treatment,and has a certain advantage on pain relief,recurrence prevention and security.Professor Zhou Naiyu is an expert of traditional Chinese medicine,and she is the third,forth,fifth batch of inheritance of traditional Chinese medicine academic experience teaching guidance teacher,she has accumulated rich clinical experience,independent-minded about diseases such as rheumatoid arthritis,the experiences are worthy enough to summary and further excavate.ObjectiveCombing the Professor Zhou Naiyu's cases in the treatment of rheumatoid arthritis,excavating the experience of famous professor in traditional Chinese medicine,to summarize the academic thought of diagnosis and treatment of the disease,and provide the reference for the improvement of clinical curative effect of traditional Chinese medicine in the treatment of rheumatoid arthritis.Methods3.1According to the case and exclusion criteria,collect outpatient medical record for the treatment of rheumatoid arthritis of Professor Zhou Naiyu.Typepatients' medical record information(basic information,symptoms,disease,syndrome classification,drug)into the Excel spreadsheet,standardize information,and we can establish a medical record database.3.2By using traditional Chinese medicine inheritance support system to analyze the data via descriptive analysis,drug frequency statistics,association rules and complex system entropy clustering,to summarize the characteristics and rules of Zhou Naiyu's treatment of rheumatoid arthritis,and combined with the research of traditional Chinese medicine syndrome differentiation,in order to explore the characteristics of Professor Zhou Naiyu in treating the disease.OutcomesIn this research,Professor Zhou Naiyu's treatment of rheumatoid arthritis is commonly used Liquorice,Astragalus,White peony root,Cassia twig,Semen Sinapis Albae,Squama Manitis,Rhizoma Curcumae Longae and Rhizoma Wenyujin,Radix sileris,Radix rehmanniae preparata,Radix stephaniae tetrandrae,Scorpion,Angelica sinensis,Psoralea corylifolia,Salvia miltiorrhiza,Atractylodes macrocephala Koidz,Rhizoma drynariae,Radix bupleuri,Cortex Dictamni Radicis,Radix Clematidis,Radix Aconiti Lateralis Preparata.When treating rheumatoid arthritis,Professor Zhou Naiyu uses lots of sweet and warm nature drugs.The top five Channel Tropism is in the liver,spleen,lungs,stomach,and kidney.In the analysis of cold dampness syndrome with the highest proportion,followed by the retention of damp heat,phlegm and blood stasis syndrome.By the pharmaceutical efficacy of the classification,nourishing was the most frequently used,next is blood-activating and stasis-resolving,diaphoretic,wind-damp dispelling drugs,antipyretic.Professor Zhou Naiyu commonly used drug combinations with Licorice,White peony root;Astragalus,Licorice,White peony root;Squama Manitis,Semen Sinapis Albae;Astragalus,Cassia twig;Astragalus,Angelica sinensis,etc..These drugs combinations with tonifying qi spleen,qi and nourishing Yin,replenishing qi and blood,invigorate the circulation of phlegm conform to the treatment of rheumatoid arthritis of Professor Zhou Naiyu's academic thought.ConclusionsProfessor Zhou Naiyu's attitude about intrinsic factors of rheumatoid arthritis are the deficiency of the spleen-kidney-yang and the deficiency of qi and blood.The Cold dampness is the most important exogenous pathogenic factor.Thus in the treatment of rheumatoid arthritis of traditional Chinese medicine,she emphasizes to consolidate the constitution.She always first to tune up qi and blood and warmly invigorating spleen and kidney.At the same time,Professor Zhou Naiyu pays attention to the phlegm-damp,stagnant blood,and liver-qi stagnation syndrome in the pathogenesis of rheumatoid arthritis.So she often uses the methods of Resolving Phlegm,Removing Blood Stasis and Soothing the Liver throughout the treatment.She uses Astragalus Cassia twig five soup commonly in order to supplement qi,warm meridian and arthralgia due to blood stasis.Professor Zhou Naiyu often use the Radix Bupleuri decoction to relieve liver-qi,and use worm drugs to dredge collateral and relieve pains.