The Pathomechanisms And Treatments Of Pathological Scar

Part 1:The Pathomechanisms and Treatments of Pathological ScarEvery physical injury to the human skin leaves a footprint in the form of a scar which can range in appearance from hardly visible to extensively disfiguring.It's the inevitable process of human trauma repair product.In the process of wound healing,the unbalance between anabolic and degradative metabolism lead to pathological scar formation.Scar management has been one of the major problems of plastic surgery.Because of its pathogenesis isn't clear,the perfect treatment isn' t exist.At present,the comprehensive treatments are widely recommended.Unfortunately,there aren't uniform classification of the cutaneous scar,and the treatments are varied,so it's difficult to decide which treatment should be adopted.This review focuses on the pathogenesis,molecular basis,clinical classification,treatment and flowchart of hypertrophic scar and keloid.Hope to provid a standard reference of the comprehensive treatment of hypertrophic scar and keloid.Part 2:Comprehensive Treatments for Keloids in Aural Region after Pierced EarsObjective:To explore the comprehensive treatments for keloids in aural region after pierced ears.Methods:One patient with keloid in the ear was treated with surgical resection and no tension suture.After 3 weeks,we used local injection with triamcinolone acetonide(Kunming JiDa)40mg +hyaluronidase(Shanghai First Biochemical Pharmaceutical Co.,Ltd.)1500u+2%lidocaine 2ml + stroke-physiological saline solution lml to preventive the recurrence of keloid.Results:The keloid were completely removed and follow up for 44 months without recurrence.Conclusion:After surgical resection of ear keloid combined with the injection of triamcinolone acetonide and hyaluronidase can prevent the recurrence of keloid and it is worth further exploration and clinical popularization.