Research Progress Of MiRNA-128 In Tumor

MiRNAs are newly discovered small-molecule non-coding RNAs with a size of about 21-25 nucleotides in recent years.These miRNAs play an important role in the regulation of gene expression at post-transcriptional level.MicroRNA-128(miR-128)is a class of brain tissue-enriched miRNAs that play an important role in the development and maintenance of the nervous system.In recent years,more and more studies have found that miR-128 may play an important role in tumorigenesis and maintenance through participating in the regulation of tumor cell proliferation,differentiation,apoptosis,invasion,angiogenesis,and drug resistance.The expression and localization of miR-128,in-depth study of target gene regulation and related signaling pathways,it will be possible to further clarify its role in tumor biology,and is expected to provide a new target for tumor diagnosis,prognosis and treatment.This article reviews the recent development of mi R-128 in cancer research.