Comparative Analysis Of Short-term Prognosis Of Leukoaraiosis Patients With Different Degrees Of Cerebral Infarction

Objective:To investigate the possible risk factors of acute cerebral infarction with leukoaraiosis(LA),and to analyze the effect of different degrees of LA on short-term prognosis of acute cerebral infarction.Methods:selected within 48 hours of hospitalization in 271 consecutive patients with acute cerebral infarction.collected clinical data(including age,gender,hypertension,diabetes,low density lipoprotein cholesterol(LDL-C),high homocysteine,Transient ischemic attack(TIA)or stroke history,coronary atherosclerotic heart disease,smoking and drinking(daily >100g),education,etc.)or stenosis of carotid artery plaque.According to the MRI T2 weighted and fluid inversion recovery(FLAIR)sequence with LA imaging,using semi quantitative Fazekas LA scale assessment and stratification of the selected cases were divided into simple,113 cases with cerebral infarction,cerebral infarction and 158 cases of group LA,and LA in patients with cerebral infarction were divided into mild group,moderate group in 51 cases 59 cases and 48 cases of severe group according to the severity of LA,were admitted to hospital,fourteenth days after treatment,1 months after the U.S.National Institutes of Health Stroke Scale(NIHSS),modified Barthel index(MBI)and Montreal cognitive assessment(MoCA Beijing)for evaluation,comparative analysis.Results :(1)and the simple group compared with LA group of patients age,hypertension,diabetes,carotid plaque and stenosis ratio increased significantly,there were significant differences,age/respectively(62.50±11.21,68.37 + 8.32,P<0.01),hypertension / cases(%)[70(61.9%),125(79.1%,P<0.01]),diabetic patients / cases(%)[35(31%),73(46.2%),P<0.05],carotid artery plaque or stenosis / cases(%)[45(39.8%),84(53.2%),P<0.05].(2)with mild LA group on admission,fourteenth days after treatment,follow-up of 1 months of NIHSS,MBI and MoCA score and pure cerebral infarction group were no significant difference(P>0.05);group LA with simple,moderate andsevere groups of patients with cerebral infarction admission NIHSS,MBI and MoCA were not significant the difference(P>0.05),compared with fourteenth days after treatment,follow-up of 1 months of NIHSS,MBI and MoCA scores in the severe group with pure cerebral infarction group were statistically significant(P<0.05),and the difference is more obvious in severe LA group(P<0.01).(3)within 7 d,companion in LA,the severe group progress the incidence of stroke in patients with relatively high pure and LA mild group,with significant difference(P < 0.05),hospitalization within 14 d correlation of stroke incidence of pneumonia,urinary tract infection,with the increased severity LA,significantly increased(compared with the pure and mild group),which the highest incidence of severe pneumonia correlation stroke in LA group,the more significant difference(P <0.01),and the intestinal complications such as infection,upper gastrointestinal bleeding and bleeding associated with severity LA has no obvious.Conclusion:1.age,hypertension,diabetes,carotid plaque or stenosis is a risk factor for cerebral infarction in patients with LA;2.LA is a prognostic factor in patients with acute cerebral infarction and the short-term outcome of poor prognosis,with the aggravation of LA poor prognosis.