| Past studies have found a strong relationship between drinking and health.Alcohol consumption has been suggested to be relevant to atherosclerotic risk factors,such as hypertension,obesity and diabetes.However,other factors,such as diet,smoking,occupation,exercise level,religion,and familial environment might confound the observational associations between alcohol consumption and cardiovascular traits.In the present study,we first announced a new cardiovascular study cohort:South Chinese Community Cohort?SCCC?.We tested the association of5 SNPs with alcohol use,BMI,blood pressure and total cholesterol,triglycerides,HDL cholesterol and LDL cholesterol within this cohort.We found strong evidence for the association of rs671 in the ALDH2 gene with alcohol drinking(Carrying the G allele,P=6.08×10-47,ORadj=4.50,ORhom=19.97,ORhet=8.12,ORGcarrier=13.78)and blood pressure(G allele increased 1.992 mm Hg of SBP(P=7.64×10-4)and 1.579mmHg of DBP(P=6.45×10-5).By the sex-stratified analysis,we found that female G carriers of rs671 had high proportion of non-drinker than male G carriers,in non-drinker?88.01%vs 38.70%?.Besides,we approved that rs7593130C was associated with an increase BMI(P=3.20×10-4,0.342 kg/m2 per C allele)and waist circumference(P=2.79×10-4,increasing 0.952 cm per C allele).We testified that rs964184,rs1800588 and rs1003723 were associated with triglyceride,total cholesterol level and LDL-C,respectively.Lastly,we evaluated the causal impact of alcohol use and BMI on cardiovascular traits through a bi-directional MR analysis.It was suggested that alcohol use were shown to have a causal effect on blood pressure(P=9.62×10-5 for DBP,and P=9.67×10-4 for SBP). |
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