Athletes Aerobic Exercise After Serum MG53 And Exercise-induced Muscle Damage Diagnosis Index Creatine Kinase,Myoglobin Correlation Studies

Objective: Exercised-induced muscle damage(EIMD)is one of the exercise injuries.The blood biochemical indicators of athletes with exercise-induced muscle damage are Creatine Kinase,Myoglobin and Blood urea Nitrogen.We found that there has a newly protein which discovered as the membrane repair protein specifically distributed in cardiac and skeletal muscle.There is a synergy mechanism between MG53 and other several membrane repair protein which repair skeletal sarcolemma.On the basis of this study,the aim of this study was to investigate the correlation among the MG53 and serum Creatine Kinase(CK),Myoglobin(Mb)and Blood Urea Nitrogen(BUN)in different aerobic exercise modes and exercise time.Methods: The experiment of 16 male athletes(Mean age 23.13±2.92,Mean age5.13±2.92,National second grade athletes)in venous blood was collected on an empty stomach quiet condition.On the next morning,the sample from athlete’s venous blood was collected on an empty stomach quiet condition before cycling endurance sports.0 h 1 h,4 h and 24 h after exercise the sample from athlete’s venous blood was collected at each time point.Obtained a venous blood for high intensity interval training of 2 weeks.The sample from athlete’s venous blood was collected on an empty stomach quiet condition before cycling endurance exercise.0 h 1 h,4 h and 24 h after exercise the sample from athlete’s venous blood was collected at each time point.Two type of testing interval of a week after collecting venous blood again.Detect serum Creatine Kinase,Myoglobin and Blood Urea Nitrogen.The result of the data is analyzed by SPSS Statistic 22.0 software.Results: Different time points and movement mode:(1)In cycling endurance exercise,There was no significant difference in serum CK between different time points(P> 0.05).Mb at 1h,4h and 24 h after exercise were more significantly higher than that of Mb at 0h(P <0.01);BUN at 0h was higher than base value of BUN(p <0.05).BUN at 1h and 4h was significantly higher than base value of BUN(p <0.01),BUN at 24 h after exercise was significantly lower than that at 1h and 4h after exercise(p <0.01).There was no significant difference in MG53 at each time point(P> 0.05).(2)In High-Intensity interval training,There was no significant difference in serum CK between different time points(P> 0.05);Mb at 1h and 24 h after exercise was significantly increased than Mb at 0h(P<0.01).There was no significant difference in BUN at each time point(P> 0.05).There was no significant difference in MG53 at each time point(P> 0.05).At the same time point with different movement modes :(1)4hours after exercise,cycling endurance exercise Mb was significantly higher than the High-Intensity interval training(p <0.05).(2)In cycling endurance exercise,BUN wassignificantly higher than that of high-Intensity interval training at 0h,1h and 4h after exercise.The correlation between MG53 and different biochemical criterion:(1)In cycling endurance exercise,Mb was positively correlated with CK at 4h after exercise(r=0.755p<0.01),Mb was positively correlated with CK 24 hours after exercise(r=0.711 p<0.01),MG53 had no correlation with CK,Mb and BUN at different time points.(2)In High-Intensity interval training,At different time points,CK and Mb showed different degrees of correlation,MG53 had no correlation with CK,Mb and BUN at different time points.Conclusion:(1)Cycling endurance exercise and High-Intensity interval training Mb、BUN significant change.(2)Cycling endurance exercise on 0h、4h serum Mb,BUN changes significantly.(3)Human MG53 increased immediately after exercise compared to pre-exercise.(4)There was no correlation between CK,Mb,BUN and human MG53 at different time points(base value,0h,1h,4h,24h)with different type of exercises.(5)Human MG53 and serum CK and Mb were different after aerobic exercise and they change the cycle is different.