The Influence Of Neutrophil To Lymphocyte Ratio On The Prognosis Of Pancreatic Cancer

Objective: To investigate the effect of neutrophil count and lymphocyte count ratio(Neutrophil to Lymphocyte Ratio,NLR)on the prognosis of patients with pancreatic cancer.Methods: the clinical data of 105 patients with pancreatic cancer who underwent radical surgery from January 2010 to January 2013 were analyzed retrospectively.Univariate analysis of Log-rank was used to investigate the effects of clinical pathological features,including NLR,on the 1 year survival rate and median survival time.Multivariate analysis was performed by using Cox risk model.Results: according to the results of blood routine examination,preoperative NLR calculation,on the basis of the four sub sites,divided into 2.1,NLR < 2.1 < NLR < 2.8,2.8 < NLR < 4.3,NLR = 4.3,four groups,each group of patients with postoperative median survival time was 25 months,16 months,11 and 5 months.2.1,NLR < 2.1 < NLR < 2.8,2.8 < NLR < 4.3three 1 year survival rate were 84.7%,79.8%,36.2%,wherein NLR = 4.3 group of patients 1 years survival rate is less than 5%.The difference was statistically significant(P< 0.05).Multivariate analysis showed that preoperative peripheral blood NLR,tumor diameter,tumor differentiation,lymph node metastasis,vascular invasion,tumor T staging and distant metastasis were independent prognostic factors in patients with pancreatic cancer(P < 0.05).Conclusion: preoperative peripheral blood NLR can be used as an indicator for evaluating the prognosis of patients with pancreatic cancer after radical surgery.