Study On Perioperative Coagulation And Heparin Resistance In Children With Congenital Heart Disease Of Uygur And Han Nationality

Objective: To observe the changes of blood coagulation indexes in children with congenital heart disease of Uygur and Han nationality in Xinjiang during car-diopulmonary bypass.Methods: 320 Uygur and Han children with congenital hea-rt disease were randomly selected from our hospital.Blood samples were collecte d at preoperative,postoperative and postoperative 24 h time points,to observe the change of PT,APTT,FIB,TT,PLT,Operation time,cardiopulmonary bypass time,24-hour chest drainage,concentration of red blood cells,plasma dosage and other general information between the two groups.According to the platelet count and national 320 cases can be divided into four groups:W1: Uyghur PLT<240×109/L;W2: Uyghur PLT>240×109/L;H1 group: han PLT<240×109/L;H2 grou-p: h an PLT>240×109/L.To observe the effect of preoperative PLT count on ACT an d Comparison of heparin anticoagulant effect for four groups.Result: 1.There we re no significant differences in PT,APTT,FIB,TT,PLT between Uygur and Han children at different time points(P>0.05).postoperative 24 h chest draina-ge,con centration of red blood cells,plasma dosage Uygur group were significantl-y highe r than those of Han children(P<0.05).2.W2 compared with H2,there was sign ificant difference in the effect of preoperative platelet count on ACT(P<0.05).Th e incidence of heparin resistance in W2 group was significantly higher tha-n Han group(P<0.05).The incidence of heparin resistance was signifycantly hig-her in Uygur children than Han children(5.2%).Conclusion: 1.There were no s-ignifica nt differences in blood coagulation indexes in children with con-genital he-art disease of Uygur and Han nationality in Xinjiang during cardiopulmonary bypa-ss.how ever,postoperative 24 h chest drainage,concentration of red blood cells and plasm a dosage of Uygur were higher than Han children.2.Preoperative platelet count i s greater than 240×109/L Uighur children in extracorporeal circulation were more likely to lead to ACT perioperative shortened,Uighur children with heparin resista nce ratio is higher than the han nationality children.