Factors Affecting Cerebrospinal Fluid Opening Pressure In Patients With Spontaneous Intracranial Hypotension

Objective:Spontaneous intracranial hypotension(SIH)is recognized far more commonly than ever before.Though usually characterized by low cerebrospinal fluid(CSF)pressure,some patients with SIH are observed to have normal pressure values.In this study,we aimed to confirm the proportion of patients with normal CSF openingpressure(CSF OP)and explore the factors affecting CSF OP in SIH patients.Methods:We retrospectively reviewed 206 consecutive SIH patients and analyzed their clinical and imaging variables(including demographic data,body mass index,duration of symptoms,and brain imaging findings).Univariate and multivariate analyses were performed to identify the potential factors affecting CSF opening pressure.Results:In a total of 114(55.3%)cases the CSF OP was ?60 mmH2O,in 90(43.7%)cases it was between 60 and 200 mmH2O,and in 2(1.0%)cases it was>200 mmH2O.Univariate analysis showed that the duration of symptoms(P<0.001),body mass index(BMI)(P<0.001)and age(P=0.024)were positively correlated with CSF OP.However,multivariate analysis suggested that only the duration of symptoms(P<0.001)and BMI(P<0.001)were strongly correlated with CSF OP.A relatively high R2 of 0.681 was obtained for the multivariate model.Conclusions:Our study indicated that in patients without a low CSF OP,a diagnosis of SIH should not be excluded.BMI and the duration of symptoms can influence CSF OP in SIH patients,and other potential factors need further investigation.