| ObjectiveComparative analysis the clinical characteristics of corynebacterium with granulomatous lobular mastitis with non-Corynebacterium infection,explore the difference between the two groups,to improve the understanding of the clinical characteristics of these patients.MethodA retrospective clinical data analysis method,the patients divided into two groups according to the pathological diagnosis of granulomatous lobular mastitis(GLM)and bacteria culture of in January 2015-September 2016 in the hospital,group A:the coryneform bacteria infection of granulomatous lobular mastitis patients;Group B:non-Corynebacterium infection patients.Two groups of patients data used to establish database,using test,rank and inspection,Fisher's exact probability statistical method,discuss the differences of clinical characteristics in two groups and related factors may affect the bacterial culture results,the conclusion.Results1 general situationCorynebacterium infection in the patients with disease from the last production time averaged 4.09±2.50 years and non Corynebacterium infection(3.98±4.82 years),compared to the onset of coryneform bacteria infections from the last production for longer periods of time,the difference was statistically significant(P<0.05).There were no significant differences in Corynebacterium infection GLM patients with an average onset age,number of the composition of the onset age,birth,breast-feeding,length,distance at the end of the time during lactation time,lactation mastitis,contralateral breast trauma history,history of oral contraceptives,history of depression are no significant differences(P>0.05).2 clinical manifestationsThe tumor size of corynebacterium with granulomatous lobular mastitis with an average of 7.24+2.89 cm,bigger than the other group(6.42+2.82 cm),and the difference was statistically significant(P<0.05).The nipple orynebacterium with GLM patients,there may be short or sag and nipple discharge,unilateral or bilateral breast disease,flush red swelling,beginning of mass concentration in peripheral quadrants,pain and swelling,fever and limbs in the course of illness erythema,the above performance similar to the non-Corynebacterium infection patients(P>0.05).3 Clinical classification,stage and syndrome differentiation of admissionWhen the GLM patients were admitted to the hospital,the clinical stages were mainly abscess and acute phase,and the initial clinical syndrome was seen in the early stages of admission.The difference was not statistically significant(P>0.05)compared to those who were not.4 other indicatorsThe readmission rate of GLM with Corynebacterium infection was higher than that of Corynebacterium negative group,the difference was statistically significant(P=0.00<0·05).There was no statistically significant difference in the level of GLM hyperprolactinemia associated with Corynebacterium infection(P=0.10>0.05)compared with that of Corynebacterium negative group.Corynebacterium infection in patients with GLM based distance average length of the disease was 2.02+2,12 months,compared with the coryneform bacteria infections,merger coryneform bacteria infections is shorter,the difference was statistically significant(P<0.01)The infection period of GLM infection with Corynebacterium infection was more concentrated,and most of them were pus,which was similar to that of Corynebacterium negative group.Conclusion:In patients with GLM infected with Corynebacterium,the onset time was longer,the mass was relatively large,and the rate of readmission was higher.Corynebacterium infection GLM patients were the onset of long distance is shorter,suggesting that we may detect more conducive to the early onset of Corynebacterium,from the last production time is more long,the physiological changes in breast ducts may be more conducive to the growth of bacteria.However,most of the clinical features between the two groups were not significantly different.GLM,which is considered to be a Corynebacterium infection,is not necessarily a specific mastitis. |
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