The Correlation Between Sleep Duration And The Incidence Of Diabetes And Impairment Of Renal Function

Objective and backgroundAs one of the most important physiological activities,sleep is closely related to many diseases of human body.Too long or too short sleep time is considered the prevalence of risk factors.In this study,we observed the relationship between sleep duration and the glucose metabolism or the incidence of diabetes,and the correlation between sleep duration and renal dysfunction.MethodsWe collected the sleep time,glucose metabolism and renal function data of 609 subjects of a community in Zhejiang,Hangzhou.According to the WHO diagnosis standard of diabetes,609 subjects were divided into three groups:normal glucose group,impaired glucose regulation group,diabetes group;according to creatinine clearance rate(Ccr),609 subjects were divided into two groups:normal renal function group,impaired renal function group.Logistic regression analysis was used to compare the correlation between different sleep time and the glucose metabolism and impaired renal function.For people without diabetes who were followed up for 4 years,analysis of the influence of different sleep duration on the incidence of diabetes was carried out.ResultsA total of 609 subjects were involved in the analysis,including 54 patients of impaired glucose regulation and 92 patients of diabetes mellitus.The incident of impaired glucose regulation was significantly increased in the very short sleep time group(<5h/d),which compared to normal sleep group(7-9h/d),OR value =5.804(95%CI=1.675-20.117,p=0.006).It shows that the too short sleep time has a correlation with impaired glucose regulation.The incident of impaired glucose regulation and diabetes was not significantly increased in the short sleep time group(5-7h/d)and long sleep duration group(>9h/d),compared to normal sleep group(7-9h/d).After a follow-up of 4 years for non-diabetic patients,the incidence of new onset diabetes in very short sleep time group(<5h/d)was significantly higher than ’the incidence of new onset diabetes in normal sleep time group(7-9h/d).Sleep time less than 5h/d is the independent risk factor for diabetes.In female diabetic patients,the very short sleep time group(<5h/d)and the short sleep time group(5-7h/d)more easily become impaired renal function compared to normal sleep time group(7-9h/d),(OR=5.98,95%CI=1.19-30.03,P=0.03).ConclusionSleep time less than 5h/d is associated with impaired glucose regulation.Sleep time less than 5h/d is the independent risk factor for diabetes.In female diabetic population,sleep time less than 7h/d is associated with renal function damage.