The Relationship Between The Diabetic Peripheral Neuropathy And The Gastromotility Disorder In Patients With Diabetes

Background: At present the means on the early diagnosis of Diabetic gastromotility disorder(DGMD)are lack of ?At present the means on the early diagnosis of Diabetic gastromotility disorder(DGMD)are lack.The results of reserch on the relationship between gastrointestinal hormone and DGMD are more than which on the relationship between Diabetic peripheral neuropathy(DPN)and DGMD,and there are few articles which research the relationship between the severity of DPN and DGMD.Objective: to understand different degree of risk of gastrointestinal disorders in patients with DPN,By detecting the stomach electrointestinogram,Methods: 75 patients with type 2 diabetes were included in this study,43 males and 32 females,with a mean age of 55.6 ± 10.7 years.The patients were divided into three groups based on electromyography and clinical symptoms: no lesion group,mild-severe lesions group,and the relation among 3 groups.Ectrogastrogram(EGG)were performed 6 minutes preprandial and 6 minutes postprandial,and underwent a detailed evaluation of the symptoms of DPN and digestive tract symptom,the Survey of electromyography,fasting and postprandial blood glucose,glycosylated hemoglobin,and blood fat,then we can study the correlation of these parameters among the three groups of patients.Results:(1)the clinical data of three groups of patients: gender,age,BMI,there was no statistical significance(P > 0.05)difference comparison,three groups of patients with diabetes duration difference was statistically significant,then through LSD test except for mild lesions and pathological changes of moderate group no difference,all other comparison between the two groups are different and no lesion group average course of the disease and in patients with mild-to-moderate lesions have difference(P = 0.002,P2 = 0.013),No lesions respectively the average duration of less than patients with mild-to-moderate lesion group(no pathological changes and pathological changes of mild-to-moderate group average difference of 5.59 and 4.19 respectively).Related biochemical indexes of three groups of patients,fasting glucose,glycosylated hemoglobin,blood lipid were rising trend,but there was no statistically significant difference(P > 0.05).(2)of three groups of patients before a meal amplitude and pre-dinner reaction area according to the severity of neuropathy,in turn,is on the decline,but there was no statistically significant difference(P > 0.05);Three groups of patients after a meal,after eating reaction area,volatile after the meal and pre-dinner power than are,in turn,is on the decline,the differences between the three groups was statistically significant(P < 0.05).(3)from the clinical data of diabetes patients with gastric electrical parameters of correlation analysis(table 3),BMI and pre-dinner amplitude,pre-dinner reaction area showed a negative correlation(r = 0.260,P = 0.024;r = 0.265,P = 0.265),BMI and postprandial amplitude,postprandial reaction area not related Age,course of diseases,respectively,and negatively correlated with the value F(r = 0.236,P = 0.041;r = 0.358,P = 0.358),FBG,HBA1 C,BMI was positively correlated with F value(r = 0.306,P = 0.008;r = 0.230,P = 0.048;r = 0300,P = 0.009),age,duration,FBG,HBA1 C and gastric electrical parameter pre-dinner amplitude,postprandial amplitude,pre-dinner RA and postprandial RA are not related.Conclusion: The electrogastrogram of patients with early stage of diabetes peripheral neuropathy would be abnormal,and with the degree of peripheral neuropathy be serious,electrogastrogram become much abnormal.The lesion degree of DPN was positively correlated with DGMD,so that can be a good parameter to predict the severity of DGMD.