The Jishengshenqiwan Pill Experimental Study On The Impact Of Diabetic Peripheral Neuropathy

ObjectiveWe established the rats in diabetic peripheral neuropathy model to observe the effects of the Ji Sheng Shen Qi improvement decoction"(JSSQ) on the blood glucose, body weight, blood TG and TC, the nerve conduction velocity and ultrastructure in these rats.This experiment was to investigate the mechanism of the protective effect on the early diabetic peripheral neuropathy of SJT and provide an experimental basis for further investigating and clinical use. MethodThe diabetes rats were induced by injecting Streptozotocin(STZ) into their abdomen successfully, and they were stochastic divided into four groups: diabetic model group (10 rats), SJZ group (10 rats), Metformin group (10 rats), the other 10 normal rats were the normal control group.The respective dosage of drugs was given to the treated groups and the same dose of sodium chloride injection was given to the normal and model series by stomach rearing once per day for eight weeks.After therapy, the blood glucose, body weight, blood TG and TC, hemorrheology, ,the nerve conduction velocity and ultrastructure of each group were tested. Result1 Body weight There were no significant differences among all group before treatment(P>0.05).After treatments, the body weight of the high dosage group was distinctly heavier than that of the model group, drug group respectively(P<0.01).2 Blood glucose There were no significant differences among the blood glucose of all the treatment and model groups. The blood glucose of every treatment group was more lower than that of the model group(P<0.01).The blood glucose of the high dosage group was more lower than that of the drug group, respectively(P<0.01).3 TG and TC The TG and TC of every treatment group was more lower than that of the model group(P<0.01).There were no obvious difference among the low dosage group, the high dosage, the drug I and drug II group.4 The nerve conduction velocity The nerve conduction velocity (NCV) of Every treatment group and model group was more slower than that of the normal group.TheNCV of the high dosage and the drug group was distinctly faster than that of the model group. The SNCV of the high dosage group was faster than that of the drug II group. Conclusion:JSSQ can significantly improved the function of nerve and protect the ultrastructure of myelinated nerve.It certainly has protective role on the rats with the early diabetic peripheral neuropathy, deserving to be researched and developed more.