Comparison Of The Clinicopathological Characteristics Of Diffuse Signet Ring Cell Carcinoma And Non-diffuse Signet Ring Cell Carcinoma

Objective:To compare the difference of clinicopathological characteristics between the diffuse signet ring cell carcinoma and non-diffuse signet ring cell carcinomaMethods:A total of 317 signet ring cell carcinoma which underwent surgery during January 2009 to December 2015 in the Department of Surgical Oncology in First Hospital affiliated to Zhejiang University were analyzed in retrospectively.We set up 73 cases in diffuse group and 244 cases in non-diffuse group respectively.Among the latter group,the gender ratio is about 1.5.Then we make comparisons in terms of the age,gender,tumor location,tumor size,lymph node metastasis,TNM stage between two groups.We use SPSS software for data processing and analyzing.Results:The results show that the age and gender of diffuse group and non-diffuse group doesn’t have significant differences.The tumor location of diffuse type and non-diffuse type has statistical significance(p<0.001).The most common location of diffuse type was whole stomach(80.3%),while the non-diffuse type were the distal stomach(39.6%)and gastric body(34.6%).The average diameter of the diffuse type is 10.03±3.70(cm),while the non-diffuse type is about 4.40±2.88(cm).The tumor size of two types has statistical significance(p<0.001).According to TNM stage,70.8%of the diffuse type belong to T4a stage and 20.8%belong to T4b stage.23.7%of the non-diffuse type is T1 stage,43.2%is T4a stage and 1.6%is T4b stage(p<0.001).The diffuse type were more frequently of the N3 stage,and the non-diffuse type tended to be NO and N2 stage(p<0.01).Conclusions:The clinicopathological characteristics of diffuse SRCC and non-diffuse SRCC are quite different,including the location and size of tumor.And part of cases among non-diffuse type were early-stage gastric carcinoma,while the diffuse type tended to be advanced gastric cancer.The level of CEA and CA199 increased much significantly among the diffuse type than the non-diffuse type.According to the differences between two types,perhaps there is a significant variety at the molecular level of genetics.