Pathological Study Of Endoscopic Submucoal Dissection For Early Gastric Cancer

Object:(1)To investigate the significance of Magnifying endoscopy with Narrow-band imaging(ME-NBI)in the diagnosis of early gastric cancer(EGC).(2)To evaluate the relationship between the expression of Run-3 and ?-catenin protein in EGC with the clinical factors.Methods:(1)we retrospectively analyzed the clinical data of all patients with ESD in the First Affiliated Hospital of Medical University Of Anhui from January2014 to December 2015,and Statistical analysis were performed using SPSS20.0software.(2)Immunohistochemistry(IHC)was used to detect the expression of Runx-3and ?-catenin protein in 30 cases of normal gastric mucosa and 49 cases of EGC.Results:(1)The correct rate of ME-NBI in the diagnosis of early gastric cancer was70.11%(61/87),and the sensitivity was 93.88%(46/49).(2)The expression rate of Runx-3 protein in normal gastric mucosa(86.67%)was significantly higher than that in EGC tissues(34.69%)(P<0.05).?-catenin staining was strongly positive(100%)in normal gastric mucosa compared with that in EGC(57.14%)(P<0.05),While The abnormal expression rate of ?-catenin(0%)was significantly lower than that in EGC tissues(75.51%)(P<0.05).No correlation was found between the expression of Runx-3and ?-catenin protein with the clinicopathological factors,including sex,age,tumor size except vessel invasion.Conclusion:(1)Applying ME-NBI will contribute to the diagnosis of EGC.(2)The reduced expression of Runx-3 in EGC indicates that it may be used as a favorable marker for the diagnosis of EGC.The loss of ?-catenin protein membrane expression while ectopic expressed on nuclear or cytoplasm in EGC and the membrane expression of ?-catenin protein was completely absent in the early stage of vascular invasion suggesting that the expression of ?-catenin protein is closely related tothe occurrence and development of EGC.A join-detection of Runx-3 and ?-catenin expression will be helpful for the diagnosis of EGC.