Prognostic Analysis And Comparison Of The Efficacy And Complication Of Different Radiotherapy Techniques For Postoperative Early Cervical Carcinoma

Objective: To explore the factors affecting the postoperative prognosis of early cervical carcinoma and investigate the different radiotherapy techniques.Methods: A total of 100 patients with early postoperative cervical carcinoma treated in Xinjiang Medical University Affiliated Tumor Hospital and Affiliated Tumor Hospital of Sun Yat-sen University from March to September 2013 were enrolled in our study.The prognostic factors for patients diagnosed with early postoperative cervical carcinoma were analyzed.After being subjected to different postoperative radiotherapy techniques,the efficacy and complications of the techniques were assessed for patients,including 50 cases of conventional radiotherapy(CRT)and 50 cases of image guided radiotherapy(IGRT).Results: In the IGRT group,the inter-fractional setup errors in the x,y,and z axes were(0.25±0.14)cm,(0.26±0.16)cm,and(0.24±0.18)cm,respectively;the intra-fractional setup errors in the x,y,and z axes were(0.1±0.09)cm,(0.12±0.09)cm,and(0.11±0.09)cm,respectively;The margins in the x,y,and z axes were 0.75 cm,0.84 cm,and 0.78 cm,respectively.The three-year overall survival rate was 89%,and the three-year disease-free survival rate was78%.The three-year overall survival rates of the CRT and IGRT groups were 78.57% and 89.06% respectively.The difference between these rates was statistically significant(P=0.034).The three-year survival rates of the CRT and IGRT groups were 66.67% and 87.36% respectively.The difference was statistically significant(P=0.042).The incidence of early and late complications in the CRT group was higher than that in IGRT group,and the difference of P<0.05 was statistically significant.Multivariate analysis showed that postoperative radiotherapy,parametrial invasion,lymph node metastasis,lympho-vascular space invasion,perineural invasion,and deep stromal invasion were the independent risk factors for the prognosis of patients with early stage cervical squamous cell carcinoma.Conclusions: Early prognosis of cervical carcinoma results from the interaction of multiple factors.The three-year survival rate of the IGRT group was significantly better than that of the CRT group in the early stage of cervical carcinoma.IGRT alleviates acute and chronic toxicities and helps improve the quality of life of patients.