| Objective:To analyze 60 cognitive impaired patients who were clinical evaluated in a hospital of Jilin University from January 2014 to January 2017,and to assess the risk factors related to cognitive dysfunction,and to speculate that the occurrence and development of hippocampal atrophy and cognitive dysfunction,in order to provide some key clues for early diagnosis and early intervention of cognitive dysfunction.Methods:60 cognitive impaird patients were collected from January 2014 to January 2017 in one hospital of Jilin University and were divided into three cohorts : Dementia patiects,mild cognitive impaired(MCI)individuals,and healthy controls.The levels of blood pressure(systolic blood pressure),fasting blood glucose,low density lipoprotein,carotid artery ultrasonography,and 3.0T head MRI ofthe three cohorts were clinically evaluated.MMSE and MOCA sub-scores of each subject were collected as well as60 cognitively normal older adultswho were control group,and the related items and all clinical data were collected too.The data were analyzed by SPSS22.0 statistical software.The t test was used to test measurement data data.X2 test was used to analyze categorical data.The continuous variables were analyzed by PEARSON.The classification variables were analyzed by SPEARMAN.Logistic regression analysis was used to analyze the risk factors.P <0.05 The difference was statistically significant.Results:1.There was no significant difference in the age and gender of the patients across dementia group,mild cognitive impairment group and control group.The educational level of the MCI and the control groups was higher than that of the dementia group and the control group had higher educational level than the MCI group,p = 0.000,was statistically significant.2.The hippocampus in cognitive impaired patients all has a certain degree of atrophy,and the hippocampal atrophy of MTA grade was positively correlated with patient age,that is,the higher the age,the higher the atrophy of hippocampus;and MOCA score was negatively associated with the severity of the hippocampus atrophy.The clinical severity of the cognitive impaired was positively associated with the homocysteine and the degree of atherosclerosis.3.The correlation analysis in MMSE and MOCA scores and the risk factors showed that MMSE score was positively correlated with education level.MOCA score was positively correlated with educational level and positively correlated with high density lipoprotein cholesterol.4.Cognitive dysfunction was associated with DB history.In the CI group,the fasting blood glucose(P=0.023),low density lipoprotein(p=0.046),homocysteine(P=0.001)and carotid atherosclerosis(P=0.019)is higher than that of the non cognitive impairment group.There was statistical significance.5.Logistic regression analysis showed that the low density lipoprotein cholesterol,homocysteine,hippocampal atrophy(MTA grade 2 ventricle enlargement of temporal horn)are independent risk factors for cognitive impairment,P< 0.05 was statistically significant.Conclusion:1.There is a positive correlation between MOCA scores and education level in patients with cognitive impairment patients,indicating that higher education level may be a protective factor for cognitive impairment.2.The degree of hippocampal atrophy is positively correlated with age,and was positively correlated with the level of homocysteine and carotid atherosclerosis.3.Cognitive dysfunction is associated with the fasting blood glucose,diabetes,low density lipoprotein cholesterol,high density lipoprotein cholesterol,homocysteine,carotid atherosclerosis degree,hippocampal atrophy MTA grade correlation.4.Low density lipoprotein and blood homocysteine,accompanied by atrophy of the temporal horn are the independent risk factor for cognitive impairment. |
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