Risk Factors Analysis About Sclerosing Pneumocytoma Metastasis And Clinical Comparison Between Elderly And Young Lung Cancer

Part one:Risk factors analysis about sclerosing pneumocytoma metastasisObjective:The aim of the paper is to study the possible risk factors of metastasis for sclerosing pneumocytoma(SP).It could be offered some reference for clinical to assess whether metastasis could occurs and improve the awareness level of SP.Methods:Retrospective studies were performed on 55 patients were diagnosed with SP between January 2000 and December 2016 in Dalian Medical University and 25 case reports of SP with metastasis were searched by Pubmed,CNKI and WANFANG DATA.Metastasis group and the control group were divided by whether SP with lymphatic or distant organ metastasis.Grouped as follows:The Metastasis group contains 26 cases aged between 10-76 years old(average 41.2±19.0)and the control group contains 54 cases aged between 22-77 years old.According to previous reports,risk factors included were age,gender,site of the tumor and size of tumor.SPSS 19.0 was used for statistical analysis and multivariate logistic regression analysis was done for risk factors with significant meaning in single factor analysis.P value less than 0.05 was regarded as statistically significant.Results:1.The overall condition of research objects:11 male(13.8%,average age 35.2±12.6)and 69 female(86.2%,average age 48.4± 15.0)patients with a total average age of 46.6± 15.4 were included.There were 26 patients with SP metastasis and 54 patients without metastasis.2.In the SP metastasis group,the proportion of male was significantly higher than that of females and the difference had statistical significance.3.There was no statistical significance in the relationship of age and SP metastasis both in male and female group(P>0.05).Ignore the influence of age,the result still had no statistical significance(p=0.057).4.The relation between site of the tumor and SP metastasis had no statistical significance(P=0.212).5.The relation between size of the tumor and SP metastasis had statistical significance(P=0.004).6.Multivariate logistic regression analysis done for risk factors with significant meaning in single factor analysis(gender,size of tumor)show that these factors could be independent risk factors of SP metastasis.Conclusions:In the suspected risk factors for SP metastasis,gender and size of tumor were closely related with metastasis and could be independent risk factors.Age was possibly related and the influence of site of the tumor was still not be proved.Part two:Clinical comparison between elderly and young lung cancerObjective:Through the comparison of clinical manifestations between elderly and young lung cancer patients,the paper aims to improve the understanding of the clinical characteristics of lung cancer in elderly,and offer help for early detection and early diagnose.Methods:With retrospective survey and analysis,we selected the patients diagnosed with lung cancer between January 2012 and December 2016 through case search system of Dalian Medical University.Patients under the age of 40 were selected for the young group,patients admitted to the same period and reached or exceeded 65 years old were randomly selected for the elderly group.Clinical data of the two groups of patients was collected,and SPSS 19.0 was used to analyze the data for statistical analysis.The comparisons of the differences between groups of count data were tested by X2,and P value less than 0.05 was regarded as statistically significant.Results:1.A total of 211 patients were included in the study:123 males(58.3%)and 88(41.7%)females.The young group contains 59 patients with an average age of 35.2±12.6,and the elderly group contains 152 patients with an average age of 71.18±4.70.2.The proportion of male in young group was lower than that in elderly group and the differences was statically significant(P=0.047<0.05).The proportion of smoking history in elderly group was significantly higher than that in young group and the differences was statically significant(P<0.001).3.The proportion of patients accompanied by lung disease in elderly group was higher than that in young group and the differences was statically significant(P=0.047<0.05).4.Most of the pathological pattern of two groups was pancreatic cancer.The incidence of squamous cell carcinoma in elder group was significantly higher than that in young group(P=0.002<0.05)and there was no significant difference in pathological distribution.5.Cough was the common symptoms of both two groups.However,the differences between proportions of each starting symptom was of no statistical significance.Conclusions:Compared with lung cancers in youth,the proportion of male,smoking history and accompanied by lung disease was higher in elderly lung cancer patients.Most of the pathological pattern was pancreatic cancer,however,the incidence of squamous cell carcinoma in elder group was significantly higher than that in young group.There was no significant difference in pathological distribution,and result of first visit in small cell carcinoma patients turned to be advanced stage.Cough was the common symptoms of both two groups.The differences between proportions of each starting symptom was of no statistical significance.