The Clinical Observation On The Treatment Of Drug-Induced Liver Injury (DILI) With Baweijiangmei Decotion And Magnesium Isoglycyrrhizinate (MgIG)

OBJECTIVE:To investigate the effects of Chinese herbal medicine,Ba Wei Jiang Mei Tang combined with magnesium isoglycyrrhizinate(MgIG)on TCM symptoms,signs,serum biochemical indexes,B-ultrasonography,then evaluate the curative effect of the treatment of DILI,and to provide a new treatment for the clinical treatment of DILI patients.METHODS:Methods:All cases were selected from September 2015 to December 2016 in Jiangsu Province,Chinese medicine hospital infection department of DILI patients,including outpatient and inpatients.Patients who met the criteria were randomly assigned to two groups of 30 patients.The control group was given conventional treatment of magnesium isoglycyrrhizinate,the treatment group in the control group based on the combination of self-made Ba Wei Jiang Mei Tang,were treated for 6 weeks.To observe and record the changes of liver function,discomfort symptoms,B-ultrasonography,analysis of efficacy,and observe the changes of blood,urine,feces and electrocardiogram and renal function before and after treatment,and to analyze the safety effect.Results:(1)Symptom,the statistical analysis,the first 3 weeks of treatment,the treatment group was effective in 30 cases,ineffective 0 cases,the effective rate of 100%;the control group was 15 cases,15 cases,the total effective rate of 50%.At the 6th week of treatment,the treatment group was cured in 1 case,markedly effective in 27 cases,effective in 2 cases,ineffective in 0 cases,the total effective rate was 100%;the control group was effective in 5 cases,effective in 23 cases,ineffective in 2 cases,the total effective rate of 50%.The overall efficacy of the two groups was significantly different(P<0.01).There was significant difference(P<0.01)between the two groups of patients after 3 weeks and 6 weeks of TCM syndromes(P<0.01).After treatment,the symptom scores were significantly lower than those before treatment,the difference was statistically(P<0.01).Between the two groups:the treatment of three weeks,AST,AKP,GGT three with significant difference(P<0.05),ALT,TB has a statistically significant difference(P<0.01);6 weeks between the two groups,P value All>0.05,no significant difference.The analysis of the group:the treatment group:There are 3 weeks,6 weeks before the indicators and treatment obvious statistical difference(P<0.01);6 weeks and 3 weeks comparison,AST Item no significant difference(P=0.737);,ALT,AKP,GGT,TB item has significant difference(P<0.01).Control group:3 weeks when there were significant statistical difference(P<0.01),AKP,GGT,TB item no statistically significant difference(P>pre-AST,ALT and treatment of two indicators 0.01);6 weeks of(P<0.01).There was significant difference between the 6th week and the 3rd week(P<0.05).There was significant difference between the two groups(P<0.05).There was no significant difference between the two groups in the treatment group at 0,3 and 6 weeks.There was no significant difference between the two groups(P<0.05).There was no significant difference between the two groups(P<0.05)Two groups of patients during this study did not appear obvious adverse reactions,blood,urine,fecal routine,electrocardiogram,renal function and so on are related to this medication related to abnormal changes.Conclusion:Ba Wei Jiang Mei Decoction combined with magnesium isoglycyrrhizinate is effective in the treatment of drug-induced liver injury,which is better than that of magnesium isoglycyrrhizinate alone in improving symptoms and signs and liver function of patients.