Aspirin Resistance In Hospitalized Patients With Coronary Artery Disease

Objective: To study aspirin resistance (AR) and evaluate its clinical characteristics in the aspirin-treated patients with coronary artery disease. Methods: 148 Patients enrolled from the First Affiliated Hospital of Xinjiang Medical University including 76 Uygur patients and 72 the Han nationality patients with stable coronary artery disease received 100mg/d of aspirin. Aspirin resistance was analyzed by examination of blood platelet aggregation induced by adenosine diphosphate(ADP) and arachidonic acid (AA). Aspirin resistance was defined as aggregation of ≥70% with 10μM ADP and aggregation of ≥20% with 0.5 mmol/L AA .Aspirin semiresponders(ASR) were defined as meeting either of the above criteria. Results: Among the patients studied, 5.4%(8/148) were aspirin resistance and 27.7% (41/148) were aspirin semiresponders. Analysis of multi-factor logistic regression to the enrolled patients' clinical data indicate that either aspirin resistance or aspirin semiresponders were significantly correlated with age(OR=0.873,95%CI: 0.803-0.949;P=0.001),sex(OR=0.098, 95%CI: 0.015-0.636; P=0.015)and LDL concentration(OR=0.162,95% CI:0.064-0.408;P=0.000). There were no differences between Uygurs and the Hans. Conclusion: This study detect 5.4% aspirin resistance and 27.7% aspirin semiresponders in 148 aspirin-treated patients with coronary artery disease. Aspirin resistance or aspirin semiresponders by platelet aggregation might be not associated with race.