| Objective:This study,based on randomized controlled clinical trial,is aimed to compare the quality of life(QOL)of patients with advanced non-small cell lung cancer(NSCLC)who receives the combined treatment of strengthening the spleen and reducing phlegm and chemotherapy with DP scheme with those who receives the treatment of chemotherapy with DP scheme only,which provides clinical basis for widely application of strengthening the spleen and reducing phlegm in lung cancer and other malignant tumors,and objectively evaluates the clinical curative effect,and maximizes characteristics and advantages of the Chinese medicine treatment for lung cancer.Methodology:60 cases of advanced non-small cell lung cancer patients are randomly divided into 2 groups,of which 30 patients in the controlled group receive the combined treatment of the strengthening the spleen and reducing phlegm with DP scheme,and another 30 cases undergo DP chemotherapy only under the observation of 2 periods of treatment,with the application of EORTC QLQ-LC43,international questionnaire of QOL,as a measurement tool,with the combination of traditional evaluation indexes(such as TCM syndrome,tumor curative effect,curative effect,tumor behavior index)as reference.Results:1.Objective curative effect:30 cases of the treatment group patients,including 1 case of complete remission,15 cases of partial remission,12 cases of stability,2 cases of progress,which is valid,accounting for 53.3,with 93.3%of disease control rate;30 cases of the controlled group,no case of complete remission,8 cases of partial remission,13 cases of stability and 9 cases of progress,with 26.7%effective rate,and disease control rate is 70%.The difference is statistically significant between the 2 groups(P<0.05).2.The efficacy of TCM symptoms:8 cases of 30 cases of the treatment group are cured with the curative effect of TCM syndrome,20 cases are effective,2 cases are invalid,with efficiency of 93.3%;2 cases of 30 patients in the controlled group are markedly effective,19 cases are effective,9 cases are invalid,with efficiency of 70%,there are statistically significant differences between the 2 groups(P<0.05).3.KPS score:the KPS score of treatment group increases from 72.33±4.30 to 79.33±7.39,the KPS score of the controlled group rises from 74.33±5.04 to 75.33±6.81,KPS score of the 2 groups of patients before treatment are not significant(P>0.05),but after treatment the difference is significant(P<0.05).4.Comparison of tumor marker CEA:CEA value of treatment group decreases from(68.73±54.81)ng/ml to the(27.98±22.70)ng/ml,with statistically significance(P<0.05);CEA value of group control decreases from(74.92±53.80)ng/ml to(50.88±39.73)ng/ml,without statistical significance(P>0.05).There are statistically significant differences between the 2 groups(P<0.05).5.Comparison of adverse reactions:there are significant differences after treatment between the 2 groups in nausea,vomiting,diarrhea and constipation(P<0.05).6.The quality of life scores:body,role,social function,general health questionnaire and fatigue,insomnia,loss of appetite,constipation symptoms and lung cancer specific sub scale score of the 2 groups after treatment are statistically significant(P<0.05).Conclusion:In this research,the combination of strengthening the spleen and reducing phlegm with DP scheme can improve QOL of patients with advanced NSCLC,have the objective curative effect and obviously alleviate symptom,and enhance the physical strength with no side effects,which is worthy of promotion. |
