Meta-analysis Of Risk Factors For Bronchopulmonary Dysplasia Among Very Low Birth Weight Infants In China

Objective Using evidence-based medicine method to analysis the risk factors of bronchopulmonary dysplasia among very low birth weight infants.Method searching systematically in Pub Med,Embase,Wan-fang database,China journal full-text database and Chinese science and technology journal full-text database,the Cochrane controlled clinical trials database,Chinese biomedical literature database(CBM)from their establishment to May 2016.Evaluating the quality of literature and software Stata 11.0 was used for a Mate-analysis.Results 15 controlled trials were included in the study,Mate analysis showed premature rupture of membranes(OR=1.90,95% CI: 1.16 ~ 3.11),pulmonary hyaline membrane disease(OR = 6.46,95% CI: 4.47 ~ 9.35),oxygen time(RR = 3.01,95% CI: 1.34 ~ 4.69),and pulmonary infection(OR = 15.76,95% CI: 7.51 ~ 33.07),after birth asphyxia(OR = 2.23,95%CI: 1.09 ~ 4.57),prenatal infection(OR = 3.41,95% CI: 2.40 ~ 4.84),PDA(OR=3.39,95%CI:2.04~5.64),gestational age(RR = 2.34,95% CI: 2.34 ~ 1.27),birth weight(RR=2.08,95% CI: 2.08 ~ 1.21)were risk factors of bronchial pulmonary dysplasia of VLBW infants;Prenatal application PS(OR = 4.09,95% CI: 1.65 ~ 10.12)is the protective factors.Conclusion we should take preventive measures for risk factors for bronchial pulmonary dysplasia of VLBW infants to reduce the incidence,survival and long-term quality of BPD in life.