| Objective:Detection of serum retinol binding protein 4(RBP4),and clinical significance in patients with coronary heart disease.Method:Coronary artery angiography(CAG)was performed in 210 patients with coronary heart disease who were admitted to the Department of cardiovascular medicine,and the patients with coronary heart disease(CHD)were diagnosed as coronary heart disease(n= 160).The patients were divided into 69 cases of acute myocardial infarction(AMI group),35 case of unstable angina pectoris(UAP group)and 56 case of stable angina pectoris(SAP group);According to the coronary artery lesions,vesseles were divided into single vessel group(40 cases),double vessel lesion group(63 cases),multi vessel disease group(57 cases);According to the Gensini(GS)score of four points,the patients were divided into mild lesion group(n = 36),moderate lesion group(n = 46),severe lesion group(n = 44),and severe lesion group(n = 34).50 patients with normal coronary angiography were enrolled as control group.All patients were fasted for 12 hours after admission to the hospital the next morning from the elbow vein blood 3ml,concentration of serum RBP4,HCY and hs-CRP detection.Analysis of the relationship between the three and its correlation with coronary heart disease and coronary artery disease.The incidence of major adverse cardiovascular events(MACE)was measured in the patients with acute coronary syndrome(ACS)after the first months of admission,followed up for a period of 6 months.Result:1.compared with the control group,the levels of RBP4,HCY and h-CRP in serum of AMI group,UAP group and SAP group were significantly higher(P <0.01).2.AMI group,UAP group,RBP4、HCY and h-CRP levels were significantly higher than that of SAP group(P<0.05);there was no significant difference between the level of serum RBP4 in AMI group and UAP group had no statistical significance(P>0.05).3 single vessel disease group,double vessel group and multi vessel disease group serum RBP4,HCY and h-CRP levels were significantly higher than that of the control group(P <0.05),with the increase of coronary artery lesion,serum RBP4,HCY and H-CRP levels were significantly increased,the difference between groups was statistically significant(P<0.05).4.mild group,moderate stenosis group,severe stenosis group and severe lesion group serum RBP4 was significantly higher than the control group,the difference was statistically significant(P<0.05),there was significant difference between the groups was statistically significant(P<0.05).5.Based on the median value(28mg/L)of BP4,the incidence of MACE of those acute co ronary syndrome(ACS)pectoris who have higher plasma RBP4 levels than median val ue issignificantly higher(46%)than those acute coronary syndrome(ACS)pectoris who havelower plasma RBP4 levels than median value during the follow up period(8%).6.There is a positive correlation between the plasma RBP4 level and Gensini Scores,HCY,Hs-CRP,LDL-C,the correlation coefficient.(r=0.859,P <0.01,r=0.491,P<0.05;r=0.671,P<0.01);a negative correlation between HDL-C.Conclusion1.The level of serum RBP4 in CHD group were significantly higher than the control group,AMI group,UAP group,serum RBP4 level were significantly higher than that of SAP group,suggesting that RBP4 may be an independent risk factor of coronary heart disease.2.The level of serum RBP4 in patients with coronary heart disease with coronary artery lesions increased significantly,and it is associated with the lesions and Gensini score positively,suggesting that serum RBP4 levels can reflect the severity of coronary artery disease.3.Serum RBP4 level can be used as a reference index to evaluate the severity and prognosis of patients with coronary heart disease. |
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