Research Of Expression And Significance Of Th17/Treg In Peripheral Blood In Patient With Acute Cerebral Infarction

ObjectiveThe purpose is to detect the expression of T helper cell 17(Th17)in peripheral blood of patients with acute cerebral infarction and explore the significance of balance between Th17 and Treg(Th17/Treg).MethodsAcute cerebral infarction(ACI)group(72 cases)and healthy control(HC)group(48cases)were investigated.The levels of Th17 and Treg in peripheral blood were detected by Flowcytometry.According to National Institute of Health stroke scale(NIHSS)scores,ACI group was divided into light group(12 cases),medium group(34 cases)and severe group(26 cases).According to the Pullicino formula,divided into small infarction volume group(17 cases),medium infarction volume group(29 cases)and big infarction volume group(26 cases).In addition,the corrolations between Th17,Treg or Th17/Treg and risk factors of patients,NIHSS orinfarction volume were statisticed respectively by SPSS.ResultsTh17,Treg or Th17/Treg and risk factors of patients,such as age,gender,hypertension,diabetes and hyperlipidemia,had no correlations(P>0.05).The level of Th17(7.26%±1.92%)and Th17/Treg(2.38±1.80)increased significantly(P<0.05)and the level of Treg(4.29%±1.82%)decreased significantly(P<0.05),compared with HC group(7.26%±1.92%,2.38±1.80,8.03%±1.10%).The level of Treg decreased significantly(P<0.05)in acute cerebral infarction.The level of Th17 cells and Th17/Treg in heavy group were higher than that of medium group and HC group(P<0.05)and the level of Treg lower(P<0.05).The level of Th17 cells and Th17/Treg in medium group were higher than that of light group and HC group(P<0.05)and the level of Treg lower(P<0.05).The level of Th17 cells andTh17/Treg ratio in big volume group were higher than that of medium volume group and HC group(P<0.05)and the level of Treg lower(P<0.05).The level of Th17 cells and Th17/Treg ratio in medium volume group were higher than that of small volume group and HC group(P<0.05)and the level of Treg lower(P<0.05).Th17,Treg and NIHSS,infarction volume had no linear correlation(P>0.05).The correlation between Th17/Treg and NIHSS,infarction volume were significantly positive(r=0.865,r=0.672,P<0.05).ConclusionTh17 and Treg and Th17/Treg are closely related to the severity of acute cerebral infarction.To a certain extent,detecting the change of Th17/Treg can assessment progression of the disease.