The Study Of Clinical Observation Of Bushenhuoxue Cycle Therapy In The Treament Of Thin Endometrium In Frozen-thawed Embryo Transfer

ObjectiveIn recent years,IVF-ET has developed an important part of reproductive medicine.Although the IVF-ET technology in the improvement and update constantly,and have a satisfactory success rate,there are still some problems,such as low implantation rate,higher cycle cancellation rate,the main reasons for these problems are the quality of embryo and endometrium receptivity problems and so on.Endometrial receptivity affect implantation of fertilized eggs,poor endometrial growth is an important factor in implantation failure.For IVF-ET,a suitable endometrial environment is a prerequisite for successful embryo transfer.At present,more and more patients with thin endometrium,thus eliminating the transplant cycle.Thin endometrium corresponds to infertility in traditional Chinese medicine,kidney deficiency,blood stasis is the basic pathogenesis.The basic theory of traditional Chinese medicine based on the research and application of frozen embryo transfer cycle of Bushen Huoxue therapy,to observe the clinical effect of Bushen Huoxue cycle therapy in the treatment of patients with thin endometrium,and to explore the mechanism of Bushen Huoxue cycle therapy.in order to improve blood perfusion,improve endometrial receptivity,improve thin endometrium in patients with frozen embryo transplantation(FET)implantation rate,or reduce the cancellation rate of frozen embryo transfer cycle.MethodsThe subjects of this study were from January 2016 to December 2016 in the first affility hospital of Guangzhou University of Chinese Medicine hospital gynecological clinic,the infertility TCM clinic of Guangdong No.2 People's Hospital reproductive center,the alternative to artificial cycle endometrial thin endometrium of FET patients with a total of 40 cases were randomly divided into two groups:treatment group(Chinese medicine + progynova)and progynova the control group.(medicine + progynova)treatment group:before ovulation,taking Buqi Huoxue Bushen prescription + progynova.After ovulation to take blood HCG,taking Wenshen Huoxue Prescription + progynova.Control group:before ovulation to take blood HCG taking progynova orally.Two groups were treated for one cycle.Before and after the treatment,the changes of.endometrial thickness,uterine hemodynamics(RI)and D-dimer of two groups before and after treatment were observed,and the pregnancy rate and the rate of cases could be transfered in the two groups were compared.Results1.The changes of endometrial thickness by vaginal ultrasound were significantly different between the two groups before and after treatment(P<0.05);the treatment group was better than the control group(P<0.05).2.The changes of uterine hemodynamics(RI)and D-dimer all had significant differences in the treatment group before and after treatment(P<0.05).3.There were significant differences between the two groups in the rate of cases could be transfered(P<0.05).Conclusion1.BushenHuoxue cycle therapy shows effect on improving the thickness of endometrium.2.BushenHuoxue cycle therapy shows effect on improving uterine hemodynamics.3.BushenHuoxue cycle therapy can reduce the cancellation rate of cycles of frozen-thawed embryo transfer.