Characteristics Of Clinical Pathology And Blood Biochemical Markers In Low Back Pain Patients With Degenerative Disc Disease

Objective: Low back pain(LBP)has brought heavy economic burden to the society and family because of its high incidence,high disability and high disability.Lumbar disc disease(LDD)is the most common cause of LBP,but also lead to disability and disability of the culprit.There are many treatment methods for lumbar disc disease,and the new technology is changing with each passing day.At present,the etiology of lumbar disc herniation is mainly focused on the aspects of heredity,mechanics,molecular biology and so on.In this paper,characteristics of clinical pathology peripheral blood biochemical markers was prepared between lumbar disc disease(Group LDD)patients and healthy people through a retrospective case-control study,to provide new ideas for its prevention and treatment.Methods: This study was divided into three parts: the first part: the tendency of patients with lumbar disc disease and healthy value,the second part patients with lumbar disc disease clinical pathological changes,the third part is characteristics of peripheral blood biochemical markers in patients with lumbar disc disease.Part Ⅰ: To avoid potential bias,the general clinical data of hospitalized patients diagnosed with lumbar disc disease in Air Force General Hospital from 2008 to 2013 and healthy outpatients for routine physical examination in 2013 were adjusted by propensity matching.The data was statistically analyzed with SPSS 22.0,the data to mean + standard the difference(mean + SD),P < 0.05 was statistically significant.Part Ⅱ: HIS system was used to search the general clinical data and the MRI images of lumbar intervertebral disc disease patients in the group LDD.1.Analyze the relationship between the size of lumbar intervertebral disc herniation and age,height.2 Analyze the relationship between VAS score and age,the size of intervertebral disc. 3 Analyze the relation between Modic changes with age,height,weight,body mass index and blood pressure.Part Ⅲ: The peripheral blood biochemical markers data of 490 hospitalized patients diagnosed with lumbar disc disease in Air Force General Hospital from 2008 to 2013 and 490 healthy outpatients for routine physical examination in 2013 were investigated.The data of biochemical markers was statistically analyzed with SPSS22.0,the data to mean + standard the difference(mean + SD),P < 0.05 for the difference was statistically significant.Results: Part Ⅰ: There was no statistical significance in Group LDD and Group C of gender,age,height,weight,BMI,blood pressure,hypertension.Part Ⅱ: 1.The size of intervertebral disc in patients with Modic Ⅱ was negatively correlated with age,and was positively correlated with height.VAS score of patients with Modic Ⅱ change was positively correlated with age,and had no correlation with the size of the protrusion.3.Age,blood pressure and intervertebral disc herniation in patients with Modic Ⅱ change with was significantly higher than that of no Modic change patients;The other difference between the two groups was not statistically significant;The correlation analysis showed that: Modic changes was positively correlated with age,blood pressure and lumbar disc size,height was negatively correlated.Part Ⅲ: Triglyceride,ferritin in Group LDD was higher than in Group C and P<0.05,the difference was statistically significant;(2)The level of high density lipoprotein,total protein,albumin,globulin,creatinine,uric acid,aspartate aminotransferase of Group LDD was lower than Group C,and P<0.05,the difference was statistically significant;(3)Ferritin was higher and the serum concentration of ferritin was significantly negatively correlated with HDL,and positively correlated with TG.While in control group,such correlation didn’t exist.Conclusion:(1)The size of intervertebral disc herniation was negatively correlated with age.(2)VAS score was positively correlated with age,and was not correlated with the size.(3)Compared with healthy subjects,patients with lumbar disc disease had abnormal metabolism of lipid and protein,and the risk factors of atherosclerosis and metabolic syndrome in patients with lumbar disc disease.