Herb-induced Liver Injury Literature Analysis And Retrospective Case Series Study Of Drug-induced Liver Injury

Objective With the change of the modern disease and widely clinical application of new drugs,the clinical cases of drug-induced liver injury is rising year by year.There are deferent reason between overseas and inland,western medicine such as anti-tuberculosis drugs mainly cause drug-induced Liver Injury(Drug-induced Liver Injury,DILI),domestic Chinese herbal medicine,health care products,dietary supplements cause Liver damage cases high proportion,drugs cause severe cases of Liver failure occurs frequently.For the diagnosis and treatment of DILI,especially herb-induced liver injury(HILI)easily ignored by patients themselves,even by clinicians or misdiagnosed.The purpose of this study is based on HILI literature summary analysis,and the "real world" for the verification of hospitalized patients with DILI clinical retrospective case series studies,the disease in the clinical practice of pathogenic factors,clinical manifestations and classification,changes and clinical indexes before and after drug treatment,etc.Summary analysis,and provide reference for clinical medication.Methods(1)literature study: through the computer retrieval MEDLINE,Pubmed and China hownet database and manual refer to the way to find between Jan.12000 and Dec.31 2000,about HILI literature published at home and abroad,the HILI clinical manifestations,basic diseases and drug-induced damage quantitative research,and so on and so forth;(2)retrospective case series studies: the first affiliated hospital of anhui medical university from Sep.1,2013-2013 on Aug.31 in DILI hospitalized patients during 3 years were retrospectively analyzed.The course of the disease,in patients with suspected drug,treatment,prognosis and so on carries on the summary analysis.Results(1)literature analysis into the HILI related with 16 references,1696 cases of male to female ratio = 1:1.81,the average age(46.12 + 5.62),from medicine tothe onset of days on average 31.5 days,hospitalization period average 21.1 days,treatment effectiveness 90.54%,clinical classification is given priority to with liver cell damage type,the main symptoms are jaundice(32.7%),gastrointestinal tract reaction(25.2%),fatigue(23.5%)and o(13.6%),the three basic diseases are respectively in patients with skin disease,cardiovascular disease,joint disease,cause liver damage in identifiable components of Chinese herbal medicine in the top three,respectively is fleece-flower root,malaytea scurfpea fruit,rhizoma corydalis.(2)three years the review of hospitalized cases were collected from 315 cases of patients with average age(48.74+ 15.30),the male to female ratio = 1:1.30,Most of the drug is traditional Chinese(173cases,including herbal medicine,Chin Tradit Pat Med),medication for the first time to the onset of the average cycle was(25.72 + 22.14)days,41 to 70 years for the period of the disease,more than 40 cases accounted for 73%,is given priority to with liver cell injury cases,clinical treatment to protect liver to fall enzymatic retreat yellow is given priority to,99.05% cases have good prognosis.Conclusion Literature study and retrospective case series study of drug-induced liver injury to manifest that the rural population and the low level of education people,old people and women are more likely to suffer from DILI,reason of disease medication has particularity between sex,the majority of patients with a history of two or more drugs,combination of Chinese and western medicines phenomenon is outstanding,from medicine to the onset of the incubation period is longer,application related to drug test liver function indicators should be paid attention to.liver damage types is given priority to with liver cell type,domestic HILI high proportion.Protect liver enzyme treatment general prognosis is good.DILI caused by traditional Chinese medicine with western medicine of ALT,AST,Hb,such as liver function index is higher,Liver injury is more serious.