Expression Of Glycodelin-A In Non-small Cell Lung Cancer And Its Relationship With Patients' Clinicopathological Features And Survival

ObjectiveBeing the leading cause of cancer related death worldwide,non-small cell lung cancer is a serious threat to human health.To improve the poor survival of lung cancer patients,there is an urgent need to find new prognostic factors to predict the prognosis of patients,so as to develop individualized treatment.Several studies have proved that some kind of cancer cells can produce glycodelin-A,which tend to be a negative prognostic factor in cancer patients.But there is no clear conclusion about the role glycodelin-A plays in NSCLC patients.Our research detected glycodelin-A protein in 125 NSCLC patients and analyzed the expression status with patients'clinical and pathologic features and patients survival.MethodsThe expression of glycodelin-A was detected by immunohistochemistry.Relationship of patients' gender,age,smoking history,pathological type,histological grade,TNM stage,lymph node and surgery history with glycodelin-A expression was analyzed by chi-square test.Kaplan-Meier Survival analysis was performed according to Kaplan-Meier.Univariate and multivariate survival analysis was performed using the Cox proportional hazards model.Results1.The positive rate of glycodelin-A in lung cancer tissues was27.2%and 11.2%in tumor adjacent tissues.The positive rate of glycodelin-A in lung cancer tissues was significantly higher than that in tumor adjacent tissues.2.Glycodelin-A-positive patients had a shorter progression-free survival and overall survival.3.The results of kaplan-meier method and univariate COX analysis were consistent with each other about the significant influencing factors of progression-free survival.The significant factors of progression-free survival were TNM stage,expression of glycodelin-A,whether the patient had undergone surgery and lymph node metastasis or not.The significant factors of overall survival were TNM stage,expression of glycodelin-A,whether the patient had undergone surgery and lymph node metastasis or not.4.The COX multivariate analysis showed that the factor of surgical treatment was an,independent factor affecting the progression-free survival(p = 0.001)smoking history(p=0.017)and surgical treatment(p<0.001)were two independent factors affecting overall survival.5.Patients with positive glycodelin-A expression have shorter progression-free survival and overall survival,especially in male patients,patients older than 60 years,smoking patients,squamous cell carcinoma patients,stage III patients,poorly differentiated patients and patients with lymph node metastasis.Conclusion1.The expression of Glycodelin-A was correlated with histological type,clinical stage and whether patient underwent surgical treatment.The expression of glycodelin-A was not related to gender,age,smoking history,differentiation and lymph node metastasis.2.Glycodelin-A-positive patients had a shorter progression-free survival and overall survival.3.Glycodelin-A is not an independent prognostic factor for progression-free survival and overall survival.4.In addition,our study have found:TNM staging of lung cancer,whether patients underwent surgery,lymph node metastasis affect the patient's progression-free survival and overall survival.5.Whether underwent surgical treatment was an independent prognostic factor affecting progression-free survival(p = 0.002)and overall survival(p<0.001).