Clinical Study Of EGCG In Green Tea Have An Impact On Modulating Inflammatory Cytokines For The Management Of Radiotherapy-induced Esophagitis

BackgroundAcute radiation-induced esophageal toxicity is a common dose-limiting complication in patients with locally advanced lung cancer in the process of radiotherapy.We aimed to investigate the effects of EGCG solution on TNF-α,TGF-β,IL-1,IL-6 to show that EGCG may have preventive and therapeutic effect on ARIE.MethodsWe prospectively enrolled patients with stage III lung cancer from the Shandong Tumor Hospital & Institute in China from May 2015 to October 2016.Enrolled patients who were received concurrent chemo-radiotherapy,or radiotherapy only all treated with 3D-CRT or IMRT,received a total total dose was planned at 60–66 Gy at a 180-200cGy/day dose rate and an irradiation time of 6–7 weeks.We divided patients into two groups including EGCG treatment group and control group.Positive control patients were given EGCG solution while Meanwhile the control group was treated with the best supportive treatment.Collecting the morning venous blood to determine the TNF-α,TGF-β,IL-1,IL-6 levels before radiotherapy,middle and late stage.ResultsARIE were found in two groups.However comparing control group,acute toxicities grades decreased in EGCG group,and the difference was statistically significant(P<0.05).TNF-α,IL-1,IL-6 levels in EGCG-treated groups were significantly lower than control group(P<0.05).ConclusionEGCG may prevent the development of ARIE,perhaps by inhibiting the generation and release of the inflammatory cytokines TNF-α,IL-1,and IL-6.EGCG could decrease theincidence and severity of esophagitis in lung cancer patients receiving thoracic radiation therapy.