| BackgroundChina is one of the countries which have high incidence of liver disease.Liver cirrhosis,liver cancer and severe hepatitis are often many end-stage liver diseases.Among them,the death rate of severe hepatitis is higher.The treatment of liver diseases has been under constant exploration and innovation in China.Medical conservative treatment can improve patients' liver function in short term and may relieve the symptoms,but it has poor effect in long-term treatment.Although liver transplantation is the best way to tackle end-stage liver disease,it is limited in widely clinical use because of the lack of liver grafts,expensive late treatment and rejection.Therefore,it is very necessary to explore an economical and feasible treatment.In recent years,a large number of experimental study confirmed that autologous bone marrow stem cells has the endurable ability of generating liver cells and bile duct cells.Meanwhile,for the low cost of the treatment,easy collection of the cells,low graft rejection reaction,simple treatment process and non-violation of medical ethics,it provides new hope for the majority of the patients suffering from liver disease.ObjectiveTo explore the therapeutic effect of autologous bone marrow stem cells in the treatment of chronic severe hepatitis.MethodThis study was conducted in 72 cases of patients with chronic severe hepatitis treated in the First People's Hospital of Shangqiu from January 2015 to December 2015.All thepatients were divided into two groups.One was the control group of 34 patients receiving conventional medical treatment.The other one was the experimental group of 38 patients treated with autologous bone marrow stem cell transplantation.The thesis compared General information of the two groups of patients which included their gender,age,course of disease and clinical staging.So was done to the clinical indexes before and after the treatment which included liver function indicators,PCT targets,indexes of coagulative function,side effect and death rate.According to the analysis done to the two groups,a thorough evaluation to the effect of the treatment was made.All the statistics was taken an x2 test and a t test for statistical analysis by using the statistical software SPSS 19.0.Result1,There is no statistical significance by analyzing the general information of the two groups of patients such as gender,age and so on.2,The comparison showed that the index of PCT of the patients within the experimental group experienced a significant decrease(P<0.05)after the surgery while the index of PCT of the patients within the conventional control group experienced a slowly decrease and gradually restored to a normal level as time went by.All indexes of the patients within the experimental group showed significant improvement compared with the patients within the conventional control group eight weeks after treatment(P<0.05).3,The index of ALT of the patients in transplantation group significantly decreased after the treatment(P<0.01).The index of aspartate aminotransferase(AST)levels relatively decreased(P<0.01).The index of TBIL and DBIL have decreased to certain extent,and the latter decreased more significantly(P<0.01).ALB indicators increased significantly(P<0.01).All indexes of the patients within the stem cell transplantation group showed significant improvement compared with the patients within the conventional medical treatment group eight weeks after treatment(P<0.05).4,After transplantation,the FIB index of the patients significantly increased than that before the treatment(P<0.01).The Pt index declined(P<0.01).The index of APTT and TTalso had a certain decline,and the latter decreased more significantly(P<0.01).After 8weeks' treatment,the indicators of patients have significant difference with that of the contrast group(P<0.05).5,After the transplantation,Th17 / CD4 + T indicators of the patients decreased obviously(P<0.01).The indicators of IgG,IgA,IgM,C3 and C4 rose to some extent and humoral immunity improved a little bit(P<0.01).After 8 weeks' treatment,the indicators of patients had significant difference with that of the contrast group(P<0.05).6,After the stem cell transplant,the indicators of the C-IV,ha,LN,PIIINP of the patients had dropped in a certain extent.As time went by,the difference was becoming increasingly apparent(P<0.01).After 8 weeks' treatment,the indicators showed significant difference with that of the contrast group(P<0.05).7,The indexes of ARFI,FibroScan of the Stem cell transplant patients had dropped in a certain extent.With the extension of time,the difference was becoming increasingly apparent after the treatment(P<0.01).Eight weeks later,the indicators were of significant difference from that of the contrast group(P<0.05).8,The adverse reactions and complications of transplantation were very small.For all patients had no apparent complications in and after the operation.Two patients had low fever after the surgery,but it didn't last long.Six patients suffered from nausea and other adverse reactions.None of them suffered from infection,bleeding,hematoma and other adverse reactions.All the patients in the two groups lived normally.9,After eight weeks' treatment,the comparison of the survival rate of the patients in the two groups showed the survival rate of the patients within the experimental group was much higher than that of the patients within the conventional control group.(P<0.05).Conclusion1,Autologous bone marrow stem cell transplantation can improve the patient's liver function,blood coagulation function,serum fibrosis index,cell and humoral immune index,noninvasive imaging indicators.2,The patients with chronic severe hepatitis who undergone autologous bone marrow stem cell transplantation will occasionally suffer from some side effects of the treatment,but their lives are in no risk.3,Autologous bone marrow stem cell transplantation treatment can improve the infectious degree of chronic hepatitis gravis,and reduce the death rate. |
PDF Full Text Request