Effect Of Corticosteroids On Atrial Fibrillation After Catheter Ablation:A Systemic Review And Meta-analysis&Overview

Objective:The purpose of this meta-analysis was to explore the effect of corticosteroids on atrial fibrillation(AF)following catheter ablation.Methods:We searched PubMed,Embase and Cochrane Central Register of Controlled Trials for published articles describing the effect of corticosteroids in preventing AF recurrence after catheter ablation.Data on study and patient were extracted properly.Risk ratios(RRs)and 95%confidence intervals(CIs)were calculated by use of random-effect model,and p values<0.05 was considered significant.Results:Five studies(2 randomized controlled trials and 3 cohort studies)involving 846 patients were included in this meta-analysis.Within 1 month of catheter ablation,corticosteroids use was associated with a declined risk of recurrence of AF in RCT(RR 0.57,95%CI 0.39 to 0.85,p=0.005),but without significant effect in cohort studies(RR 1.01,95%CI 0.79 to 1.30,p = 0.94).After 3 months of catheter ablation,corticosteroids did not have a significant effect in the prevention of late recurrence of AF in both RCT(RR 0.78,95%CI 0.38 to 1.59,p=0.49)or cohort studies(RR 0.96,95%CI 0.70 to 1.31,p=0.78).Conclusion:In conclusion,our meta-analysis suggested that periprocedural administration of corticosteroids of catheter ablation was associated with reduction of early but not late recurrence of AF.